Unconventional secretion of the SARS-CoV-2 main protease opens the door for new extracellular biology in viral infection
In a recent Cell Reports paper from the Overall Lab, Grin et al. reveal the unconventional secretion of the SARS-CoV-2 main protease, 3CLpro, from infected cells into the extracellular milieu through gasdermin (GSDM)-D and GSDME pores activated by caspases.