Blood and guts: McNagny’s team identifies novel pathways involved in inflammatory bowel disease
Ulcerative colitis is a chronic inflammatory bowel disease that is increasing in prevalence, and is characterized by weight loss, diarrhea, bleeding and fever. The disorder features invasion of the intestinal wall with the white blood cells, distortion of normal glanduloar structures, and multiple abscesses. Although it is known that altered regulation of the immune response […]
First CBR Collaborative Training Awards
On December 1, 2010, two CBR trainees will each receive awards of $15,000 per year for two years. The purpose of this program, supported by the CBR and an unrestricted educational grant from Talecris Biotherapeutics, is to provide translational research opportunities for young scientists and to encourage CBR interactions. CBR trainees submitted proposals which require […]
Earl Davie Symposium 2010
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Introduction of CBR Training Awards Program
In ongoing efforts to provide translational research opportunities for young scientists and to encourage interactions between CBR groups, the CBR is offering 2 awards to trainees (MSc, PhD, post-doc, clinical fellows), each worth $15,000 per year for 2 years. This new program requires that 2 CBR PIs collaborate in supervising the trainee in a project […]
Hancock laboratory seeks novel anti-infective therapeutic strategies
Infectious diseases are responsible for a third of all deaths on the planet, and current therapeutifc approaches are under severe threat due to antibiotic resistance. The laboratory of CBR member Bob Hancock is engaged in research to address this growing problem. By using systems biology approaches to understand the mechanisms of action of antimicrobial petides […]
Leitch and Vickars identify survival benefits of iron chelation
Myelodysplastic syndromes and primary myelofibrosis are bone marrow failure disorders with a heightened leukemia risk. Affected patients require chronic red blood cell transfusions which leads to iron overload. Excess iron can cause damage to and faillure of the heart and live, and diabetes. In a series of publications, CBR investigators Heather Leitch and Linda Vickars […]
CBR Research Day 2010
One of the unique and valued features of the CBR is that it fosters translational research across multiple disciplines, with a focus on solving clinically relevant problems related to blood, blood diseases and blood processes. Multiple CBR events throughout the year encourage and facilitate interactions between CBR group members. The annual CBR Research Day is […]
Burtnick and colleagues unbury the mysteries of buried actin-binding sites
The dynamic and tightly regulated interactions of actin and actin-binding proteins determine the sape and function of all mammalian cells. Loss of integrity of these proteins and their capacity to modulate cell function under different pathophysiologic conditions are associated with a range of diseases. It is therefore critical to delineate the mechanisms underlying these interactions […]
Rossi lab finds elusive repair cell
Following damage, many organs regenerate and return to their original state. When regeneration fails, a fibrous scar tissue, often containing scattered fat cells (adipocytes), replaces the functional tissue and interferes with organ function. Preventing this process remains a challenge, and requires identification of the source of the fibrous tissue and characterization of the adult stem […]
Karsan group identify microRNAs that are important in a maligant blood disease
A study published in Nature Medicine, led by CBR investigator Aly Karsan, Professor and Medical Director of the Cancer Genetics Laboratory, BCCA, and Head of Clinical Genomic Diagnostics at the Genome Sciences Centre reveals the role of two microRNAs (miRs) in a subtype of myelodysplastic syndromes (MDS). MDS comprise a group of malignant hematopoietic stem […]