Earl W. Davie Symposium 2023: Poster Gallery

November 7, 2023

This gallery showcases the posters that were presented at the 17th annual Earl W. Davie Symposium on November 16, 2023, at UBC Robson Square. These individuals include undergraduate students, graduate trainees, postdoctoral fellows, clinical fellows, and research associates.

If you have questions about Earl W. Davie Symposium 2023 posters, please contact Kaitlyn Chuong (kaitlyn.chuong@ubc.ca).

Posters

1. Aastha Chauhan - Critical role of TRPC5 for platelet activation and in vivo recovery

Authors: Aastha Chauhan1, Anastasiia Stratiievska1, S. Lawrence Bailey1, Moritz Stolla1,2

1 Bloodworks Northwest Research Institute, Seattle, WA

2 University of Washington Medical Center, Department of Medicine, Division of Hematology, Seattle, WA

PI: Dr. Moritz Stolla

Role: Graduate Student

Download the poster (PDF).

2. Aleksander Lazarski - Structural and Thermodynamic Characterization of a Nuclease-Antitoxin Pair

Authors: Aleksander C. Lazarski, Liam J. Worrall, Natalie C.J. Strynadka

PI: Dr. Natalie Strynadka

Role: Graduate Student

Download the poster (PDF).

3. Alexandra Bohm - Antiphospholipid antibodies, cryoglobulinemia, and IgM kappa monoclonal gammopathy in recurrent small vessel thrombosis and skin ulcers: a case report

Authors: Alexandra Bohm1, Bo Angela Wan1, Amir Karin2, Lauren J. Lee3, Agness YY Lee3, Edward M Conway4, and Chieh Min Benjamin Lai3

1 Department of Medicine, UBC, Vancouver, BC

2 Department of Pathology and Laboratory Medicine, UBC, Vancouver, BC

3 Division of Hematology, Department of Medicine, UBC, Vancouver, BC

4 UBC Centre for Blood Research

PI: Dr. Chieh Min Benjamin Lai

Role: Graduate Student

Download the poster (PDF).

4. Alexandra Witt - Development of Double Mutant Clotting Factor X as a Novel Thrombolytic Agent

Authors: Alexandra Witt1,2,3, Scott Meixner2,3, Ed Pryzdial1,2,3

1 Department of Pathology and Laboratory Medicine, UBC, Vancouver, BC

2 Centre for Blood Research, UBC, Vancouver, BC

3 Canadian Blood Services

PI: Dr. Ed Pryzdial

Role: Graduate Student

Download the poster (PDF).

5. Brock Hoard - The L33P polymorphism of integrin β3 PSI domain displays enhanced thiol isomerase activity and upregulates the coagulation cascade

Authors: Brock Hoard1,2, Eric Cerenzia2,3, Preeti Bhoria4, Xi Lei4, Guangheng Zhu4, Pingguo Chen4,5 and Heyu Ni1-6

1 Department of Laboratory Medicine and Pathobiology, University of Toronto

2 Department of Laboratory Medicine, LKSKI-Keenan Research Centre for Biomedical Science, St. Michael's Hospital, and Toronto Platelet Immunobiology Group

3 Department of Physiology, University of Toronto

4 Toronto Platelet Immunobiology Group and Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto

5 Canada Blood Services Centre for Innovation

6 Department of Medicine, University of Toronto

PI: Dr. Heyu Ni

Role: Graduate Student

Download the poster (PDF).

6. Christopher Khoury - Anti-GPIbα antibodies in FNAIT associated with recurrent miscarriages

Authors: Christopher J. Khoury1-3, Pingguo Chen2-4, Guangheng Zhu2,3, Zoya Tawhidi1-3, Alan Lazarus1-4,8, Yiming Wang5, Karen Chong6,7, David Chitayat1,6,7, Heyu Ni1-4,8

1 Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, ON

2 Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON

3 Toronto Platelet Immunobiology Group, Toronto, ON

4 Canadian Blood Services Centre for Innovation, Toronto, ON

5 Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON

6 The Prenatal Diagnosis and Medical Genetics Program, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON

7 Department of Physiology, University of Toronto, Toronto, ON

8 Department of Medicine,  University of Toronto, Toronto, ON

PI: Dr. Heyu Ni

Role: Graduate Student

Download the poster (PDF).

7. Colton Strong - Genetically Engineered Transfusable Platelets using mRNA-Lipid Nanoparticles

Authors: Colton Strong1,2,3, Jerry Leung1,2,3,4, Katherine E. Badior5, Madelaine Robertson1,2,3,4, Xiaowu Wu6, Michael A. Meledeo6, Emma Kang3,7, Yusuke Sato8, Hideyoshi Harashima8, Andrew P. Cap6, Dana V. Devine2,3,7,9, Eric Jan2, Pieter R. Cullis2,4, Christian J. Kastrup1,2,3,5,10

1 Michael Smith Laboratories, UBC

2 Department of Biochemistry and Molecular Biology, UBC

3 Centre for Blood Research, UBC

4 NanoMedicines Research Group, UBC

5 Blood Research Institute, Versiti Wisconsin, Milwaukee

6 Blood and Shock Resuscitation Program, United States Army Institute of Surgical Research, Houston

7 Department of Pathology and Laboratory Medicine, UBC

8 Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Hokkaido, Japan

9 Centre for Innovation, Canadian Blood Services, Vancouver

10 Departments of Surgery, Biochemistry, Biomedical Engineering, and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee

PI: Dr. Christian Kastrup

Role: Graduate Student

Download the poster (PDF).

8. Danielle Karakas - Novel mechanisms of thrombopoietin generation: the critical role of Kupffer cells

Authors: Danielle Karakas1-3, June Li1-4, Wenjing Ma1-3, Mina Masoud1-3, Chuanbin Shen1-3, Sonya A MacParland1,5,6, Walter Kahr2,7,8, Heyu Ni1-4,9,10

1 Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto

2 Toronto Platelet Immunobiology Group, University of Toronto, Toronto

3 Department of Laboratory Medicine and Pathobiology, University of Toronto

4 Canadian Blood Services Centre for Innovation, Toronto

5 Multi-Organ Transplant Program, Toronto General Hospital Research Institute

6 Department of Immunology, University of Toronto

7 Department of Biochemistry, University of Toronto

8 Division of Hematology/Oncology, Department of Paediatrics, University of Toronto and The Hospital of Sick Children, Toronto

9 Department of Medicine, University of Toronto

10 Department of Physiology, University of Toronto

PI: Dr. Heyu Ni

Role: Graduate Student

Download the poster (PDF).

9. David Rocco - Investigating a Potential Role for Integrin Activation and Aggregation in GPIb-IX-mediated Immune Thrombocytopenia

Authors: David Rocco1, Robert H. Lee2, Wolfgang Bergmeier1,2

1 Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill

2 Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill

PI: Dr. Wolfgang Bergmeier

Role: Graduate Student

Download the poster (PDF).

10. Debajeet Ghosh - Unraveling the Interplay between miR-146a, TP53, and Inflammation in DNMT3A CHIP Pathogenesis

Authors: Debajeet Ghosh1, Vijay Akhade1,2, Jennifer Grants1, Jessica Tran2, Aly Karsan1,2

1 Genome Sciences Centre, BCCRC

2 Department of Pathology and Laboratory Medicine, UBC

PI: Dr. Aly Karsan

Role: Graduate Student

Download the poster (PDF).

11. Edward Sobczak - Placental and blood mitochondria DNA heteroplasmies in women living with HIV and their association with preterm birth

Authors: Edward Sobczak1,2, Zeshuo Li1,2, Izabella Gadawaska1,2, Hélène CF Côté1,2 and the CIHR Team in Cellular Aging and HIV Comorbidities in Women and Children (CARMA)

1 Pathology and Laboratory Medicine, UBC

2 Centre for Blood Research, UBC

PI: Dr. Hélène Côté

Role: Undergraduate Student

Download the poster (PDF).

12. Emma Kang - mRNA-LNP Engineering of Donor Platelets is Compatible with Current Blood Banking Practices

Authors: Emma Kang1,2,3, Colton Strong1,2,4, Jerry Leung1,2,4,5, Katherine E. Badior6, Madelaine Robertson1,2,4,5, Nicolas Pereyra2,4, Amanda Wietzny6, Brenda Ma2,4, Zechariah Noronha2, Dana V. Devine3,4,5, Eric Jan4, Pieter R. Cullis4,5, Christian J. Kastrup1,2,3,4,6,7

1 Michael Smith Laboratories, UBC

2 Centre for Blood Research, UBC

3 Department of Pathology and Laboratory Medicine, UBC

4 Department of Biochemistry and Molecular Biology, UBC

5 NanoMedicine Research Group, UBC

6 Blood Research Institute, Versiti Wisconsin, Milwaukee

7 Departments of Surgery, Biochemistry, Biomedical Engineering, and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee

PI: Dr. Dana Devine

Role: Graduate Student

Download the poster (PDF).

13. Felix Hong - The role of Filamin A in the Platelet Shape Change Reaction

Authors: Felix Hong1,2, Molly Y. Mollica4,5,6, Nathan J. Sniadecki6,7, José A. López4,5, Hugh Kim1,2,3

1 Centre for Blood Research, UBC

2 Department of Biochemistry and Molecular Biology, UBC

3 Department of Oral Biological and Medical Sciences, UBC

4 Bloodworks Research Institute, Seattle, WA

5 Department of Medicine, University of Washington, Seattle, WA

6 Department of Mechanical Engineering, University of Washington, Seattle, WA

7 Department of Bioengineering, University of Washington, Seattle, WA

PI: Dr. Hugh Kim

Role: Graduate Student

Download the poster (PDF).

14. Grace Kuo - Engineering CAR-Expressing Innate Lymphoid Cells (ILC) from Human Induced Pluripotent Stem Cells (iPSCs) for Cancer Immunotherapy

Authors: Grace I.C. Kuo1, Jiyoung Yun1, Ross Jones1, Laura Stankiewicz1, Michael Hughes1, Peter W. Zandstra1,4 Kelly M. McNagny1,2,3

1 School of Biomedical Engineering, UBC

2 Department of Medical Genetics, UBC

3 Centre for Heart and Lung Innovation (HLI), St. Paul's Hospital, Vancouver

4 Michael Smith Laboratories, UBC

PI: Dr. Kelly M. McNagny

Role: Graduate Student

Download the poster (PDF).

15. Dr. Haifeng Ji - The Control of Protein Binding on Bio-Interface by a Novel Coating to Prevent Contact Activation on Biomaterials

Authors: HF. Ji1,2, K. Yu1,2, S. Abbina1, L. Xu3, , T. Xu3, SJ. Cheng3, S. Vappala1, A. Arefi2, I. Chafeeva1, M. Drayton1, K. Gonzalez1 , D. Grecoy2, E.M. Conway1, WF. Zhao3, CS. Zhao3, JN. Kizhakkedathu1,2

1 Centre for Blood Research, UBC

2 School of Biomedical Engineering, UBC

3 Sichuan University, Chengdu, China

PI: Dr. Jay Kizhakkedathu

Role: Postdoctoral Research Fellow

Download the poster (PDF).

16. Henry West - Tissue Factor as the molecular basis for hemostatic disease in enveloped virus infection: HIV and dengue virus

Authors: Henry E. West2,3, Bryan H. J. Lin2,4, Michael R. Sutherland1,2,3, Cindy Lam4, Ivan Sadowski4, Marc Horwitz5, and Edward L. G. Pryzdial1,2,3

1 Canadian Blood Services, Medical Affairs and Innovation

2 Centre for Blood Research, UBC

3 Department of Pathology and Laboratory Medicine, UBC

4 Department of Biochemistry and Molecular Biology, UBC

5 Department of Microbiology and Immunology, UBC

PI: Dr. Ed Pryzdial

Role: Graduate Student

Download the poster (PDF).

17. Iryna Liubchak - The development of photopolymerizable GelMA hydrogels with tunable properties for the enhancement of axonal regeneration following spinal cord injury

Authors: Iryna Liubchak1,2, Emad Naseri1,2, Tanya Bennet1,2, Tara M. Caffrey1,2, Karen C. Cheung1,2,3

1 School of Biomedical Engineering

2 Centre for Blood Research

3 Department of Electrical and Computer Engineering, UBC

PI: Dr. Karen C. Cheung

Role: Graduate Student

Download the poster (PDF).

18. John Perrier - Coagulation Initiated by Tissue Factor on Coronavirus

Authors: John Perrier1,2, Henry West1,2, Michael Sutherland1,2,3, Ed Pryzdial1,2,3

1 Department of Pathology and Laboratory Medicine

2 UBC Centre for Blood Research

3 Canadian Blood Services

PI: Dr. Ed Pryzdial

Role: Graduate Student

Download the poster (PDF).

19. Joyce Teodoro - Selective cell propagation via laser micropatterning of a thermally-activated hydrogel

Authors: Joyce Teodoro1,2, Jeffrey Chiu1,2, Jeong Hyun Lee1,2, Kerryn Matthews1,2, Simon Duffy1,2, Hongshen Ma1,2,3,4

1 Department of Mechanical Engineering, UBC, Vancouver

2 Centre for Blood Research, UBC, Vancouver

3 School of Biomedical Engineering, UBC, Vancouver

4 Vancouver Prostate Cancer, Vancouver General Hospital, Vancouver

PI: Dr. Hongshen Ma

Role: Graduate Student

Download the poster (PDF).

20. Julliet Kien Zama - Impact of hepatitis C virus (HCV) clearance on markers of immune aging and inflammation among women living with and without human immune-deficiency virus (HIV) overtime

Authors: Julliet K. Zama1,2,3, Izabella Gadawski1, Hélène C.F. Côté1,2,3

1 Department of Pathology and Laboratory Medicine, UBC, Vancouver

2 Centre for Blood Research, UBC, Vancouver

3 Women's Health Research Institute, Vancouver

PI: Dr. Hélène Côté

Role: Graduate Student

Download the poster (PDF).

21. Kiran Toor - Renal Outcomes in Pediatric Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis in the First 24-Months

Authors: Kiran Toor1,2, Audrea Chen1, Kelly Brown1,2, David Cabral1,3, Cherry Mammen1,3, and Kimberly Morishita1,3

1 Department of Pediatrics, The University of British Columbia

2 BC Children's Hospital Research Institute

3 BC Children's Hospital

PI: Dr. Kelly Brown & Dr. Kimberly Morishita

Role: Graduate Student

Download the poster (PDF).

22. Mahsa Yazdanbakhsh - Young RBC Subpopulation Reduce the Hb-Oxygen Affinity of Cord Blood from Preterm Neonates

Authors: Mahsa Yazdanbakhsh1,2, Haytham Eid3,4, Jack Rabi3,4, Po-Yin Cheung3,5, Jason P. Acker1,2

1 Innovation and Portfolio Management, Canadian Blood Services, Edmonton AB

2 Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton AB

3 Neonatal Research Unit, Royal Alexandra Hospital, Alberta Health Services, Edmonton AB

4 Section of Neonatology, Department of Pediatrics, University of Calgary, Calgary AB

5 Department of Pediatrics, University of Alberta, Edmonton AB

PI: Dr. Jason Acker

Role: Graduate Student

Download the poster (PDF).

23. Megan Barney - Catheter Associated Venous Thrombosis among Veteran Patients

Authors: Barney ME1, Gruber J2, Tam A1, Mertzel M1, and Nguyen KP1,2

1 Oregon Health and Sciences University, Portland, OR

2 Veterans Affairs, Portland, OR

PI: Dr. Khanh P. Nguyen

Role: Graduate Student

Download the poster (PDF).

24. Michael Afe - The Impact of Age, Sex, and in utero Exposure to Antiretroviral Therapy on Relative LINE-1 Content in Infants Born to Mothers Living with HIV

Authors: Michael Afe1,2, Izabella Gadawski2, Helene C.F. Côté2,3,4, and the Children and Women: AntiRetroviral therapy and Markers of Aging (CARMA) team.

1 University of Jena, Germany

2 Department of Pathology and Laboratory Medicine, UBC

3 Centre for Blood Research, UBC

4 Edwin S.H. Leong Healthy Aging Program, UBC

PI: Dr. Helene Côté

Role: Graduate Student

Download the poster (PDF).

25. Nicole Rhoads - High-density Lipoprotein Inhibits VWF-induced Microvascular and Arterial Thrombosis in Mice

Authors: N. Rhoads1, R. Adili1, J. Harris1, J. Chen1, JA. López1, DW. Chung1

1 Bloodworks Research Institute, Seattle, WA

PI: Dr. José A. López

Role: Graduate Student

Download the poster (PDF).

26. Noa Chazot - Apolipoprotein A-IV is a Novel Endogenous Inhibitor of Thrombosis: The Roles of its Polymorphisms on Platelet Function

Authors: Noa Chazot1,2,4, Daniel T. MacKeigan1-3, Si-Yang Yu1,2, Dachuan Zhang1,2,4, Christopher J. Khoury1,2,4, Xi Lei1,2, Heyu Ni1-6

1 Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto

2 Toronto Platelet Immunobiology Group, University of Toronto

3 Department of Physiology, University of Toronto

4 Department of Laboratory Medicine and Pathobiology, University of toronto

5 Canadian Blood Services for Innovation, Toronto

6 Department of Medicine, University of Toronto

PI: Dr. Heyu Ni

Role: Graduate Student

Download the poster (PDF).

27. Pan Deng - Single-Cell Motility Analysis using Nano Well In-Microwells

Authors: Pan Deng1,2,3, Wenze Lyu2,3, Kerryn Matthews1,3, Simon Duffy1,3,4, Cherry Mammen1,3, and Hongshen Ma1,2,3

1 Centre for Blood Research

2 Department of Mechanical Engineering

3 The University of British Columbia, Vancouver, BC, Canada

4 British Columbia Institute of Technology, Vancouver, BC, Canada

PI: Dr. Hongshen Ma

Role: Graduate Student

Download the poster (PDF).

28. Paniz Ghavimi - Discovering Novel Interactions Between Thrombosis, Diabetes and Obesity

Authors: Paniz Ghavimi, Kevin Gonzalez, Nooshin Safikhan, Patricia Benedet, Edward Conway

Centre for Blood Research, UBC, Vancouver

PI: Dr. Edward Conway

Role: Undergraduate Student

Download the poster (PDF).

29. Peyman Malek mohammadi nouri - Localized Treatment of Interstitial Cystitis using a Novel Cell Surface Engineering Approach

Authors: Peyman Malek mohammadi nouri1,2, Meredith A. Clark1, Haiming D. Luo1,3, Jayachandran N. Kizhakkedathu1,2,3,4

1 Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada

2 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

3 Department of Chemistry, University of British Columbia, Vancouver, BC, Canada

4 School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada

PI: Dr. Jayachandran Kizhakkedathu

Role: Graduate Student

Download the poster (PDF).

30. Sanaz Hemmatibardehshahi- Exploring Osmotic Characteristics and Survival of Red Blood Cell Subpopulation Extremes Post-Deglycerolization: A Biotinylation Approach

Authors: Sanaz Hemmatibardehshahi1, Jason P. Acker1,2

1 Department of Laboratory Medicine and Pathology, University of Alberta

2 Innovation and Portfolio Management, Canadian Blood Services

PI: Dr. Jason P. Acker

Role: Graduate Student

Download the poster (PDF).

31. Sarah Stucky - Extracellular Actin Potentiates Platelet Aggregation through Collagen Activation Pathway

Authors: Sarah Stucky1, Xu Wang MD1, Kristyn Ringgold PhD1, Nathan J. White MD1, Susan A. Stern MD1, José A. López 2, Alexandra E. St. John MD1

1 Emergency Medicine Research Laboratory, Department of Emergency Medicine, University of Washington, Seattle, WA

2 Bloodworks Research Institute, Seattle, WA

PI: Dr. José A. López

Role: Graduate Student

Download the poster (PDF).

32. Stephanie Besoiu - Novel MHC Class I Antigens Cross Priming Ability of Type 2 Innate Lymphoid Cells

Authors: Stephanie Besoiu1,3,4,5, Pablo de Lucía Finkel1,2,3,4,7, Clara Wenjing Xia1,2,3,4,7, Cheryl G. Pfeifer1-8, Wilf Jefferies1-8

1 Michael Smith Laboratories, UBC

2 Vancouver Prostate Centre, Vancouver General Hospital

3 Department of Microbiology and Immunology, UBC

4 Centre for Blood Research, UBC

5 The Djavad Mowafaghian Centre for Brain Health, UBC

6 Department of Medical Genetics, UBC

7 Department of Zoology, UBC

8 Department of Urologic Sciences, UBC

PI: Dr. Wilf Jefferies

Role: Graduate Student

Download the poster (PDF).

33. Steven Jiang - The Role of Filamin A in Platelet MAP Kinase Activation

Authors: Steven Jiang1,2, Kalyan Golla1,2, Hugh Kim1,2,3

1 Centre for Blood Research, UBC

2 Department of Biochemistry and Molecular Biology, UBC

3 Faculty of Dentistry, UBC

PI: Dr. Hugh Kim

Role: Graduate Student

Download the poster (PDF).

34. Dr. Yu-Hsuan Huang - Defining the Differences Between Acute and Chronic Lung Fibrosis

Authors: Yu-Hsuan Huang1,2, Amos Fong1, Pamela Dean2, Savitha Singararjan1, Najmeh Assadinia4, Jacqueline Lai1, Wilder Scott2, Lesley Hill2, Manisha Dosanjh1, Stephane Filbotte3, Tille-Louise Hackeet4, T. Michael Underhill2, Calvin D. Roskelley2 & Pauline Johnson1

1 Department of Microbiology & Immunology, UBC

2 Department of Cellular and Physiological Sciences, UBC

3 Department of Bioinformatics Facility, Life Sciences Institute, UBC

4 Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC

PI: Dr. Hugh Kim

Role: Research Associate

Download the poster (PDF).

Posters will continue to be added as they become available!