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Deciphering the ‘Glycocode’ of methicillin resistant S. aureus

Deciphering the ‘Glycocode’ of methicillin resistant S. aureus

It is clear that the ‘glycocode’ (complex glycosylation process) plays a vital role in bacterial survival and pathogenicity. The authors believe that TarM and TarS would be ‘lucrative targets for novel therapeutic agents in light of an ever-decreasing antibiotic arsenal’.

The perils of a future without effective antibiotics

The perils of a future without effective antibiotics

WHO report “Antimicrobial resistance: Global report on surveillance” in 2014- the first world-wide report on antimicrobial resistance demonstrates that we may reach the post-antibiotic era this century unless we can take action on many different fronts.

Let’s Come Together: Tuberculosis Virulence Factors

Let’s Come Together: Tuberculosis Virulence Factors

In the current paper, Solomonson and colleagues solved the structure of the ESX-1 secreted virulence factor EspB, demonstrating that it has a pore-like structure, which may facilitate its proposed membranolytic function during pathogenesis.

“Protease Inhibitors in Drug Discovery” Conference Summary

“Protease Inhibitors in Drug Discovery” Conference Summary

Protease Inhibitors in Drug Discovery Conference was held on February 26-27, 2015 in San Diego, CA – hosted by GTCbio CBR members, Dr. Dieter Bromme and his postdoctoral fellow, Preety Panwar, attended the Protease Inhibitors in Drug Discovery Conference, where Preety presented her research on “Exosite inhibitors targeting cathepsin K in osteoporosis”. Her travel was […]

How flexible are your red blood cells? – Microfluidic deformability

How flexible are your red blood cells? – Microfluidic deformability

A step forward in transfusion medicine may involve a new application of microfluidics technology to evaluate the quality of stored red blood cells (RBC).

Beyond clotting: Platelets have active immunoproteasomes!

Beyond clotting: Platelets have active immunoproteasomes!

This research adds to the growing body of evidence that platelets play a bigger role in the immune system than previously thought and suggests that these small cell fragments may have more surprises in store.