Guadalupe Rojas-Sanchez
Award Recipient: Guadalupe Rojas-Sanchez, Postdoctoral Fellow, Bloodworks Research Institute
Supervisor: Dr. Pavel Davizon-Castillo
Conference: Earl W. Davie Symposium, November 13, 2024
Location: Vancouver, BC
Poster Title: TNFα-mediated autophagy inhibition disrupts platelet metabolism and hemostatic function in inflammatory diseases.
I am deeply honored to have received the Centre for Blood Research External Travel Award, which allowed me to attend the 2024 Earl W. Davie Symposium in Vancouver, marking my first visit to Canada and this prestigious event.
The symposium provided an invaluable opportunity to broaden my knowledge across various topics, including the biochemistry of von Willebrand factor, serine proteases, the roles of megakaryocytes and platelets in immunity, thrombosis, platelet signaling, and clinical research advances. Presentations from internationally recognized experts enriched my understanding of the hematological field, highlighting potential research areas and gaps worth exploring.
Guadalupe in front of her poster.
At the symposium, I presented my poster titled “TNFα-mediated autophagy inhibition disrupts platelet metabolism and hemostatic function in inflammatory diseases.” This study demonstrates a mechanistic link between inflammation, autophagy, and mitochondrial dysfunction in platelets, proposing autophagy modulation as a potential therapeutic target to restore platelet function and mitigate thrombotic and hemorrhagic complications in inflammatory diseases. Engaging with senior investigators during my presentation provided valuable insights and spurred discussions on new avenues for research.
This project is part of the ongoing work in Dr. Pavel Davizon-Castillo’s laboratory, where I am fortunate to receive mentorship as I advance my career in the hematological field.
The experience of visiting Vancouver added a unique dimension to my professional and personal growth. As my first visit to Canada, I was struck by the city’s stunning architecture, natural beauty, and vibrant culture. I also had the chance to savor the diverse and rich cuisine, which provided a delightful window into Canadian gastronomy. Most importantly, I was deeply touched by the warmth and hospitality of the Canadian people, who made me feel welcome at every turn. These experiences enriched my perspective and left a lasting impression of this beautiful country. I am profoundly grateful for the External Travel Award.
*With funding from the Sheldon Naiman and Linda Vickars Endowment Fund, the CBR supports travel and accommodation expenses for trainees to attend and present at the EWD symposium.