Kelly L. Brown

Contact Information
BC Children’s Hospital Research Institute
Room A5-141, 950 West 28th Avenue
Vancouver, BC, Canada, V5Z 4H4
Office: 1-604-875-2000 x7984
Tel: 1-604-875-2000 x7625

Current Positions

  • Assistant Professor, Dept. of Pediatrics, Division of Rheumatology, UBC.
  • Investigator, BC Children’s Hospital Research Institute.

Research Interests

Research program aims to improve assessment and management of childhood rheumatic disease by identification and incorporation of sensitive, subclinical (cellular/molecular) measures of inflammatory/immune activity into current clinical scores of disease activity.


  1. Armaroli G, Verweyen E, Pretzer C, Kessel K, Hirono K, Ichida F, Okabe M, Cabral DA, Foell D, Brown KL and Kessel C. (2018) Sterile inflammatory activation of human coronary artery endothelial cells induced by S100A12 is driven by monocyte-derived interleukin 1beta. Arthritis and Rheumatology. Accepted Nov 2018.
  2. Brown KL, Lubieniecki JM, Armaroli G, Kessel K, Gibson KM, Graham J, Liu D, Hancock REW, Ross CJ, Benseler S, Luqmani R, Cabral DA, Foell D and Kessel C on behalf of the PedVas study group. (2018) S100A12 and common inflammatory markers improve assessment of disease activity in a PedVas cohort of childhood systemic vasculitis. Frontiers in Pediatric Immunology. Accepted Oct 2018.
  3. Sundqvist M, Christenson K, NiemietzI, Osla V, Karlsson A, Dahlgren C, Speert DP, Anders F, * Bylund J and *Brown KL. (2017) Elevated mitochondrial reactive oxygen species and cellular redox imbalance in human NADPH- oxidase-deficient phagocytes. Frontiers Immunology ahead of print; published online 21 Dec 2017 *authors contributed equally.
  4. Jefferson T, Brown KL, Hiebert J, Al-Rawahi GN, Moxham JP, Krajden M, Jassem AN and Tucker LB (2017) Measles lymphadenopathy in a child with PFAPA Syndrome. Pediatric and Developmental.
  5. Westwell-Roper, C, Lubieniecka JM, Brown KL, Morishita KA, Mammen C, Wagner-Weiner L, Yen E, Li, SC, O’Neil K, Lapidus SK, Brogan P, Cimaz R, Cabral DA for the ARChiVe Investigators Network within the PedVas initiative. (2017) Clinical practice variation and need for pediatric-specific treatment guidelines among rheumatologists caring for children with ANCA-associated vasculitis: an international clinician survey. Pediatric Rheumatology Online Journal 15(1):61.
  6. Ragotte RJ, Dhanrajani A, Pleydell-Pearce J, Del Bel KL, Tarailo-Graovac M, van Karnebeek C, Senger C, McKinnon ML, Seear M, Prendiville JS, Tucker LB, Houghton K, Cabral DA, Guzman J, Petty RE, Brown KL, Tekano J, Wu J, Morishita KA, Turvey SE (2016) The Importance of Considering Monogenic Causes of Autoimmunity: A Somatic Mutation in KRAS Causing Pediatric Rosai-Dorfman Syndrome and Systemic Lupus Erythematosus. Clinical Immunology 175:143-146.
  7. Hellström Erkenstam N, Fleiss B, Smith P, Wang W, Boström M, Gressens P, Hagberg H, Brown KL, Sävman K, Mallard C (2016) Temporal characterization of microglia/macrophage phenotypes in a mouse model of neonatal hypoxia-ischemic brain injury. Frontiers in Cellular Neuroscience 10:286.
  8. Dong Y, Arif AA, Olsson M, Cali V, Hardman B, Dosanjh M, Lauer M, Midura RJ, Hascall VC, Brown KL, Johnson P. (2016) Purified hyaluronan and hyaluronan fragments do not stimulate pro-inflammatory cytokine production in dendritic cells or macrophages. Scientific Reports 6:36928.
  9. Morishita K, Brown KL, Cabral DA. Pediatric Vasculitis: Advances in Treatment (2015) Curr Opin Rheum. 27:493- 499.
  10. Lee-Sayer SS, Dong Y, Arif AA, Olsson M, Brown KL, Johnson P. (2015) The where, when, how and why of hyaluronan binding by immune cells. Front Immunol 6:150. PMID 25926830.
  11. Boulouri H, Sävman K, Wang W, Thomas A, Maurer N, Dullaghan E, Fjell CD, Hagberg H, Hancock REW, Brown KL*, Mallard C* (2014) Innate defence regulatory peptide protects against neonatal brain injury. Annals of Neurology 75:395. *authors contributed equally.
  12. Wuerth KC*, Hilchie AL*, Brown KL, Mookherjee N and Hancock R. (2013) Antimicrobial, Host Defence Peptides and Proteins (v. 3). In: Encyclopedia of Life Sciences, John Wiley & Sons Ltd DOI :10.1002/9780470015902.a0001212.pub3 *authors contributed equally.
  13. Sundqvist M, Wekell P, Osla V, Bylund J, Christenson K, Sävman K, Fasth A, Berg S, Brown KL*, Karlsson A* (2013) Increased intracellular oxygen radical production in neutrophils during febrileepisodes of PFAPA syndrome. Arthritis & Rheumatism 65:2971-2983. PMID 23983059 *authors contributed equally.


  • Postdoctoral, UBC and the Welcome Trust Sanger Institute, UK (Functional Genomics) and The University of Gothenburg, Sweden (Phagocyte Biology).
  • M.D., University of Saskatchewan, 1996.
  • PhD, Microbiology & Immunology, UBC.
  • BSc, Biochemistry, Simon Fraser University.