Contact Information
Vancouver General Hospital
Gordon and Leslie Diamond Health Care Centre
10th Fl, 2775 Laurel Street, Vancouver, BC, Canada, V5Z 1M9
Tel: 1-604-875-4952
Fax: 1-604-875-4763
Email: alee14@bccancer.bc.ca
Current Positions
- Professor, Division of Hematology, Medicine, Grant Tenure.
- Medical Director, Thrombosis Program, Vancouver General Hospital.
- Scientist, Centre for Health Evaluation and Outcome Sciences, Providence Health Care.
Research Interests
- Cancer associated thrombosis.
- Evaluation of diagnostic testing in pregnant women with suspected thrombosis.
- Novel anticoagulants.
- Clinical trials methodology.
Selected Publications
- Samuelson Bannow BT, Lee AYY, Khorana AA, Zwicker JI, Noble S, Ay C, Carrier M. Management of cancer-associated thrombosis in patients with thrombocytopenia: guidance from the SSC of the ISTH. J Thromb Haemost (in press).
- Parker A, Peterson E, Lee AYY, de Wit C, Carrier M, Polley G, Tien J, Wu C. Risk stratification for the development of venous thromboembolism in hospitalized patients with cancer. J Thromb Haemost (in press).
- Bauersachs R, Lee AYY, Kamphuisen PW, Meyer G, Janas MS, Jarner MF, Khorana AA on behalf of CATCH investigators. Renal impairment, recurrent venous thromboembolism and bleeding in cancer patients with acute venous thromboembolism – analysis of the CATCH study. Thromb Haemost (in press).
- Kamphuisen PW, Lee AYY, Meyer G, Bauersachs R, Janas MS, Jarner MF, Khorana AA on behalf of CATCH investigators. Clinically relevant bleeding in cancer patients treated for venous thromboembolism from the CATCH study. J Thromb Haemost (in press).
- Lloyd AJ, Dewilde S, Noble, Reimer E, Lee AYY. What impact does venous thromboembolism and bleeding have on cancer patients’ quality of life? Value in Health (in press).
- Douketis J, Spyropoulos AC, Andersen JL, Arnold D, Bates SM, Bavalia R, Blostein M, Carrier M, Caprini JA, Clark NP, Dentali F, Duncan J, Gross PL, Kassis J, Kowlaski S, Lee AYY, Le Gal G, Le Templier G, Li A, McKay E, Shah V, Shivakumar S, Solymoss S, Spencer FA, Syed S, Tafur AJ, Vanassche T, Thiele T, Wu C, Yeo E, Schulman S. The perioperative anticoagulant use of surgery evaluation (PAUSE) study for patients on a direct oral anticoagulant who need an elective surgery or procedure: design and rational. Thromb Haemost (in press).
- Lee AYY. When can we stop anticoagulation in patients with cancer-associated thrombosis? Hematology 2017;1:128-135.
- Lee AYY. When can we stop anticoagulation in patients with cancer-associated thrombosis? Blood 2017;130:2484-2490.
- Khorana AA, Kamphuisen PW, Meyer G, Bauersachs R, Janas MS, Jarner MF, Lee AY. Tissue factor as a predictor of recurrent venous thromboembolism in malignancy: biomarker analyses of the CATCH Trial. J Clin Oncol 2017;35:1078-1085.
- Field TS, Camden MC, al-Shimemerir S, Lui G, Lee AY. Antithrombotic strategy in cerebral venous thrombosis: differences between neurologist and hematologist respondents in a Canadian survey. Can J Neurol Sci 2017;44(1):116-9.
- Hayden A, Park S, Guistini D, Lee AY, Chen LY. Hemophagocytic syndromes (HPS) including hemophagocytic lymphohistiocytosis (HLA) in adults: a systematic scoping review. Blood Rev 2016;30(6):411-20.
- Holbrook A, Dormuth C, Morrow R, Lee A, Troyan S, Li G, Pullenyegum E. Comparative effectiveness and safety of oral anticoagulants for atrial fibrillation in real-world practice: a population-based cohort study protocol. BMJ Open 2016;6:e013263.
- Lee AYY, Peterson E, Wu C. Clinical practice guidelines on cancer-associated thrombosis: a review on scope and methodology. Thromb Res 2016;140 Suppl 1:S119-27.
- Sarwal G, Dandurand C, Lee AYY, Vu VH. Could anticoagulation with Rivaroxaban have precipitated a spinal epidural hematoma: From independent mobility to paraplegia. UBCMJ 2016;8(1):34-7.
- Skeith L, Rodger MA, Lee AY, Kahn SR, Bates SM, Gonsalves C. International Society on Thrombosis and Haemostasis core curriculum project: core competencies in clinical thrombosis and hemostasis: comment. J Thromb Haemost 2016;14(6):1316-7.
- Fagarasanu A, Alotaibi GS, Hrimiuc R, Lee AYY, Wu C. Role of Extended Thromboprophylaxis after Abdominal and Pelvic Surgery in Cancer Patients: A Systemic Review and Meta-Analysis. Ann Surg Oncol 2016; 23:1422-1430.
- Bates SM, Takach LS, Douketis JD, Kearon C, Julian J, Parpia S, Schulman S, Weitz JI, Linkins LA, Crowther M, Lim W, Spencer FA, Lee AY, Gross PL, Ginsberg J. Rapid Quantitative D-dimer to Exclude Pulmonary Embolism: A Prospective Cohort Management Study. J Thromb Haemost 2016; 14(3):504-9.
- Field TS, Camden MC, Al-Shimemeri S, Lui G, Lee AYY. Off-label use of novel anticoagulants for treatment of cerebral venous thrombosis: A Canadian survey. Intl J Stroke 2016;0(0):1-3.
- Lee AYY, Kamphuisen PW, Meyer G, Bauersachs R, Janas MS, Jarner MJ, Khorana AA on behalf of the CATCH Investigators. Tinzaparin vs Warfarin for Acute Venous Thromboembolism – Reply. JAMA. Jan 2016; 315(2): 200-1.
- Khorana A, Carrier M, Garcia D, Lee AYY. Guidance for the prevention and treatment of cancer-associated venous thromboembolism. J Thomb Thrombolysis 2016; 41(1):81-91.
- Lee AYY, Kamphuisen PW, Meyer G, Bauersachs R, Janas MS, Jarner MJ, Khorana AA on behalf of the CATCH Investigators. Tinzaparin versus warfarin for treatment of acute venous thromboembolism in patients with active cancer: a randomized clinical trial. JAMA 2015; 314(7): 677-86.
- Chopra V, Flanders SA, Saint S, Woller S, O’Grady NP, Safdar N, Trerotola SO, Saran R, Moreau N, Wiseman S, Pittiruti M, Akl EA, Lee AYY, Courey A, Swaminathan L, LeDonne J, Becker C, Krein SL, Bernstein SJ. The Michigan Approproateness Guide for Intravenous Catheters (MAGIC): Results From a Multi-Specialty Panel Using the RAND/UCLA Appropriateness Method. Ann Intern Med 2015; 163(6_supplement): S1-S40.
- Schulman S, Douketis J, Carrier M, Lee AYY, Shivakumar S, Blostein M, Spender FA, Solymoss S, Barty R, Wang G, Heddle N on behalf of the study investigators. Perioperative management of dabigatran: a prospective cohort study. Circulation 2015; 132(3):167-173.
- DiNisio M, Lee AYY, Carrier M, Liebman HA, Khorana AA. Diagnosis and treatment of incidental venous thromboembolism in cancer patients. SSC Committee on Haemostasis & Malignancy Communication. J Thromb Haemost 2015; 13(5):880-3.
- Schulman S, Zondag M, Linkins L, Pasca S, Cheung YW, de Sancho M, Gallus A, Lecumberri R, Molnar S, Ageno W, Le Gal G, Falanga A, Hulegårdh E, Ranta S, Kamphuisen P, Debourdeau P, Rigamonti V, Ortel TL, Lee A. Recurrent venous thromboembolism in anticoagulated patients with cancer: management and short term prognosis. J Thromb Haemost 2015;13(6):1010-8.
- Linkins L, Bates SM, Lee AYY, Heddle NM, Wang G, Warkentin TE. Combination of 4Ts score and PF4/H-PaGIA for the diagnosis and management of heparin-induced thrombocytopenia: prospective cohort study. Blood 2015; 126:597-603.
- International registry on behalf of the Subcommittees on Control of Anticoagulation and on Haemostasis and Malignancy of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Recurrent venous thromboembolism in anticoagulated patients with cancer – Management and short-term prognosis. J Thromb Haemost 2015; 13(6):1010-8.
- Wu C, Lee AYY. Options for treatment of VTE in malignancy with novel oral anticoagulants. Seminars Thromb Haemost (in press).
- Kopolovic I, Wu C, Lee AYY. Management and outcomes of cancer-associated venous thromboembolism in patients with concomitant thrombocytopenia: a retrospective cohort study. Ann Hematology 2015;2:329-36.
- Lyman GH, Bohlke K, Khorana AA, Kuderer NM, Lee AY, Arcelus JI, Balaban EP, Clarke JM, Flowers CR, Francis CW, Gates LE, Kakkar AK, Key NS, Levine MN, Liebman H, Tempero MA, Wong SL, Somerfield MR, Falanga A. Venous thromboembolism prophylaxis and treatment in patients with cancer: American Society of Clinical Oncology clinical practice guideline update 2014. J Clin Oncol 2015;33:654-6.
Education
- Master, Health Research Methodology, McMaster University.
- Hematology, McMaster University.
- Internal Medicine, University of British Columbia.
- Medicine, University of British Columbia.