Dr. Rossi’s team discovers new mechanisms to target muscular dystrophy
Researchers unraveled a mechanism governing the deregulation of connective tissue cells (FAPs) after muscle injury. The interaction between FAPs and Macrophages could be a target of the new anti-fibrosis therapies.
Dr. Dana Devine wins the CSTM ORTHO award
Canadian Society for Transfusion Medicine (CSTM) ORTHO award recognized Dr. Devine for her longstanding research career in blood products, transfusion medicine, platelet biology, complement biochemistry, and coagulation.
The Green side of CBR: Join the Sustainability Club
This month, CBR celebrates the second anniversary of the Compost Cookie Club! Most people may not be aware that the organic waste produced on campus is made into a useful product for the UBC gardeners to use on University landscapes.
Picornaviruses cleave host’s proteins to facilitate viral infection: Drs. Overall and Jan identify novel targets
Although initially viewed as ”collateral damage” resulting from viral replication cleavages in host proteins have increasingly been recognized as specific, targeted events aimed at impeding antiviral responses and facilitating viral infection.
Clearing the path for infection: E. coli Type III Secretion System
It is fascinating to behold the ingenuity by which certain bacteria achieve infection in their host. One clear example is the enteropathogenic Escherichia coli, which uses a molecular syringe and needle complex to inject its virulence proteins into the cytoplasm of host intestinal epithelial cells.
Kizhakkedathu and Withers Make Breakthrough in the Pursuit of Universal Blood
A collaborating team of CBR and UBC Chemistry scientists described the development of an improved enzyme that takes us a step closer to achieving universal blood.
Bridging the gap – challenges for women in science and academia
Over a century on, significant breakthroughs in policies and general attitudes have created opportunities for women to take their place as equals on the research stage. A closer look at diversity among scientists in both research and industry, however, reveals that a gender disparity still exists.
Kelly McNagny group developed an antibody to target the spread of aggressive tumors
Recently published in Breast Cancer Research, study showed how inhibiting podocalyxin, a protein marker found in many highly aggressive tumours, dramatically slowed the metastasis
Bromme lab discovers collagen degradation mechanisms – potential targets for osteoporosis?
This research not only provides understanding of how cathepsin K breaks down collagen fibers but also opens the door for the design of a new class of drugs selectively targeting the degradation of collagen through cathepsin K.
Deciphering the ‘Glycocode’ of methicillin resistant S. aureus
It is clear that the ‘glycocode’ (complex glycosylation process) plays a vital role in bacterial survival and pathogenicity. The authors believe that TarM and TarS would be ‘lucrative targets for novel therapeutic agents in light of an ever-decreasing antibiotic arsenal’.