Kelly L. Brown

Contact Information
BC Children’s Hospital Research Institute
Rm A5-141, 950 West 28th Avenue
Vancouver, BC, Canada, V5Z 4H4
Office: 1-604-875-2000 x7984
Tel 1-604-875-2000 x7625
kbrown@bcchr.ca

Current Positions

  • Assistant Professor, Dept. of Pediatrics, Division of Rheumatology, UBC
  • Investigator, BC Children’s Hospital Research Institute

Research Interests

Research program aims to improve assessment and management of childhood rheumatic disease by identification and incorporation of sensitive, subclinical (cellular/molecular) measures of inflammatory/immune activity into current clinical scores of disease activity.

Key Publications

  1. Sundqvist M, Wekell P, Osla V, Bylund J, Christenson K, Sävman K, Fasth A, Berg S, Karlsson A, Brown KL (2013) Increased intracellular oxygen radical production in neutrophils during febrile episodes of PFAPA syndrome. Arthritis & Rheumatism 65:2971-2983.
  2. Boulouri H, Sävman K, Wang W, Thomas A, Maurer N, Dullaghan E, Fjell CD, Hagberg H, Hancock REW, Mallard C, Brown KL (2014) Innate defence regulatory peptide protects against neonatal brain injury. Annals of Neurology  75:395.
  3. Lee-Sayer SS, Dong  Y, Arif  AA, Olsson  M, Brown KL, Johnson P (2015) The where, when, how  and  why of hyaluronan binding by immune cells. Front Immunol 6:150
  4. Morishita K, Brown KL, Cabral DA (2015) Pediatric Vasculitis: Advances in Treatment. Curr Opin Rheum 27;493-499
  5. Dong Y, Arif AA, Olsson M, Cali V, Hardman B, Dosanjh M, Lauer M, Midura RJ, Hascall VC, Brown KL, Johnson P. Purified hyaluronan and hyaluronan fragments do not stimulate pro-inflammatory cytokine production in dendritic cells or macrophages (2016) Scientific Reports 6:36928.
  6. Jefferson T, Brown KL, Hiebert J, Al-Rawahi GN, Krajden M, Moxham JP, Tucker LB (2017) Measles Lymphadenopathy Associated with Periodic Fever, Apthous Stomatitis, Pharyngitis, and Adentitis (PFAPA) Syndrome. Pediatric and Developmental Pathology ahead of print

Education

  • BSc, Biochemistry, Simon Fraser University
  • PhD, Microbiology & Immunology, UBC
  • Postdoctoral, UBC and the Welcome Trust Sanger Institute, UK (Functional Genomics) and The University of Gothenburg, Sweden (Phagocyte Biology) M.D., University of Saskatchewan, 1996