Fabio Rossi

Contact InformationFabio Rossi
The Biomedical Research Centre
2222 Health Sciences Mall
Vancouver, BC, Canada V6T 1Z3
Tel: 1-604-822-7138
Fax: 1-604-822-7815
Email: fabio@brc.ubc.ca

Current Positions

  • Co-Director, Biomedical Research Centre
  • Professor, Medical Genetics, Medicine
  • Fellow, Royal Society of Canada
  • Canada Research Chair in Regenerative Medicine.
  • Michael Smith Foundation for Health Research Fellow

Research Interests

  • Hematopoietic stem cell migration.
  • Stem cell plasticity.
  • The role of microglial cells in neurodegenerative disease.
  • Chromatin organization and lineage choice.

Publications

  1. Microglia’s heretical self-renewal Fabio Rossi and Coral lewis. Nature Neuroscience news & views, March 2018 PMID: 29593318 DOI: 10.1038/s41593-018-0123-3.
  2. Inhibition of Methyltransferase Setd7 Allows the in Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential. Robert N. Judson, Marco Quarta Menno J. Oudhoff Hesham Soliman Lin Yi Chih Kai Chang Gloria Loi Ryan Vander Werff Alissa Cait Mark Hamer Justin Blonigan Patrick Paine Linda T.N. Doan Elena Groppa WenJun He Le Su Regan H. Zhang Peter Xu Christine Eisner Marcela Low Ingrid Barta Coral-Ann B. Lewis Colby Zaph Mohammad M. Karimi Thomas A. Rando Fabio M. Rossi. Cell Stem Cell, 2018 January 23rd, http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(17)30511-8.
  3. Increased non-HDL cholesterol levels cause muscle wasting and ambulatory dysfunction in the mouse model of LGMD2B. Sellers SL, Milad N, White Z, Pascoe CD, Chan R, Payne GW, Seow CY, Rossi F, Seidman MA, Bernatchez P. J Lipid Res. 2017 Nov 25. pii: jlr.M079459. doi: 10.1194/jlr.M079459. [Epub ahead of print] PMID:29175948.
  4. Increased plasma lipid levels exacerbate muscle pathology in the mdx mouse model of Duchenne muscular dystrophy.Milad N, White Z, Tehrani AY, Sellers S, Rossi FMV, Bernatchez P. Skelet Muscle. 2017 Sep 12 PMID: 28899419.
  5. Isolation, Culture, and Differentiation of Fibro/Adipogenic Progenitors (FAPs) from Skeletal Muscle. Judson RN, Low M, Eisner C, Rossi FM. Methods Mol Biol. 2017; 1668:93-103 PMID: 28842904.
  6. A blueprint for the next generation of ELSI research, training, and outreach in regenerative medicine.Illes J, Sipp D, Kleiderman E, Benjaminy S, Isasi R, Lomax G, Master Z, McCormick J, Ogbogu U, Ravitsky V, Robillard JM, Rossi F, Wilson B, Zarzeczny A. NPJ Regen Med. 2017 Jul 5;2:21. doi: 10.1038/s41536-017-0026-z. eCollection 2017. Review. PMID:29302357.
  7. Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury. Lo BC, Gold MJ, Scheer S, Hughes MR, Cait J, Debruin E, Chu FSF, Walker DC, Soliman H, Rossi FM, Blanchet MR, Perona-Wright G, Zaph C, McNagny KM. Am J Respir Cell Mol Biol. 2017 Jul 6. doi: 10.1165 PMID: 28683207.
  8. Bone Marrow-Derived Cell Accumulation in the Spinal Cord Is Independent of Peripheral Mobilization in a Mouse Model of Amyotrophic Lateral Sclerosis. Peake K, Manning J, Lewis CA, Tran K, Rossi F, Krieger C. Front Neurol. 2017 Mar 8;8:75.PMID: 28337172.
  9. Fibro/Adipogenic Progenitors (FAPs): Isolation by FACS and Culture. Low M, Eisner C, Rossi F. Methods Mol Biol. 2017;1556:179-189 PMID: 28247350.
  10. Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration. Pisconti A, Banks GB, Babaeijandaghi F, Betta ND, Rossi FM, Chamberlain JS, Olwin BB. Skelet Muscle. 2016 Oct 4; 6:34. PMID: 27757223.
  11. Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration. Fiore D, Judson RN, Low M, Lee S, Zhang E, Hopkins C, Xu P, Lenzi A, Rossi FM, Lemos DR. Stem Cell Res. 2016 Jul;17(1):161-9. doi: 10.1016/j.scr.2016.06.007. PMID: 27376715.
  12. G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program. Antignano F, Braam M, Hughes MR, Chenery AL, Burrows K, Gold MJ, Oudhoff MJ, Rattray D, Halim TY, Cait A, Takei F, Rossi FM, McNagny KM, Zaph C. J Exp Med. 2016 Jun 27;213(7):1153-62. doi: 10.1084/jem.20151646. PMID: 27298444.
  13. The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration. Zhang RH, Judson RN, Liu DY, Kast J, Rossi FM. Skelet Muscle. 2016 May 27; 6:22. doi: 10.1186/s13395-016-0093-7. eCollection 2016. PMID:27239264.
  14. SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling. Oudhoff MJ, Braam MJ, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FM, Tatlock JH, Owen DR, Brown PJ, Zaph C. 2016 Dev Cell 37(1):47-57 PMID:27046831.
  15. Origin, fate and dynamics of macrophages at CNS interface. Tobias Goldmann, Peter Wieghofer, Marta Joana Costa Jordão, Fabiola Prutek, Nora Hagemeyer, Kathrin Frenzel, Lukas Amann, Ori Staszewski, Katrin Kierdorf, Martin Krueger, Giuseppe Locatelli, Hannah Hochgarner, Robert Zeiser, Slava Epelman, Frederic Geissmann,Josef Priller, Fabio Rossi, Ingo Bechmann, Martin Kerschensteiner, Sten Linnarsson, Steffen Jung, Marco Prinz. Nature Immunology. 2016, doi: 10.1038/ni.3423 PMID:27135602.
  16. Skeletal muscle-resident MSCs and bone formation. Lemos DR, Eisner C, Hopkins CI, Rossi FM. 2015 Jun 21. pii: S8756-3282(15)00249-5. doi: 10.1016/j.bone.2015.06.013. [Epub ahead of print] Review.PMID: 26103092.
  17. Vella S, Penna I, Longo L, Pioggia G, Garbati P, Florio T, Rossi F, Pagano A. Sci Rep. 2015 Dec 17;5:18144. doi: 10.1038/srep18144.PMID:26674674.
  18. Submyeloablative conditioning with busulfan permits bone marrow-derived cell accumulation in a murine model of Alzheimer’s disease. ​Barr CM, Manning J, Lewis CA, Rossi FM, Krieger C. Neurosci Lett. 2015 Feb 19; 588:196-201PMID: 25582787.
  19. Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. Dario R Lemos, Farshad Babaeijandaghi, Marcela Low, Chih-Kai Chang, Sunny T Lee, Daniela Fiore, Regan-Heng Zhang, Anuradha Natarajan, Sergei A. Nedospasov & Fabio M V Rossi. Nat Med 2015 Jun 8. doi: 10.1038/nm.3869. PMID: 26053624.
  20. The role of microglia in human disease: therapeutic tool or target? Cartier N, Lewis CA, Zhang R, Rossi FM. Acta Neuropathol. 2014 Sep;128(3):363-80. doi: 10.1007/s00401-014-1330-y. Epub 2014 Aug 9. PMID: 25107477.
  21. Inflammation in muscle repair, aging, and myopathies. Bouché M, Muñoz-Cánoves P, Rossi F, Coletti D. Biomed Res Int. 2014;2014:821950. doi: 10.1155/2014/821950. Epub 2014 Aug 4. No abstract available. PMID: 25162030.
  22. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, Couzens AL, Aman A, Gingras AC, Al-Awar R, Fish PV, Gerstenberger BS, Roberts L, Benn CL, Grimley RL, Braam MJ, Rossi FM, Sudol M, Brown PJ, Bunnage ME, Owen DR, Zaph C, Vedadi M, Arrowsmith CH. Proc Natl Acad Sci U S A. 2014 Aug 18. pii: 201407358. [Epub ahead of print] PMID: 25136132 [PubMed – as supplied by publisher].
  23. Collision or convergence? Beliefs and politics in neuroscience discovery, ethics, and intervention. Paylor B, Longstaff H, Rossi F, Illes J. Trends Neurosci. 2014 Aug;37(8):409-12. doi: 10.1016/j.tins.2014.06.001. PMID: 25086860.
  24. In vivo characterization of neural crest-derived fibro/adipogenic progenitor cells as a likely cellular substrate for craniofacial fibrofatty infiltrating disorders. Paylor B, Joe AW, Rossi FM, Lemos DR. Biochem Biophys Res Commun. 2014 Aug 15;451(1) PMID: 25073114.
  25. Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation. Antignano F, Burrows K, Hughes MR, Han JM, Kron KJ, Penrod NM, Oudhoff MJ, Wang SK, Min PH, Gold MJ, Chenery AL, Braam MJ, Fung TC, Rossi FM, McNagny KM, Arrowsmith CH, Lupien M, Levings MK, Zaph C. J Clin Invest. 2014 May 1;124(5):1945-55. doi: 10.1172/JCI69592. Epub 2014 Mar 25. PMID: 24667637 [PubMed – indexed for MEDLINE].
  26. The methyltransferase G9a regulates HoxA9-dependent transcription in AML. Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, Zhang R, Krosl J, Yung E, Kirschner J, Rosten P, Underhill TM, Jin J, Hébert J, Sauvageau G, Humphries RK, Rossi FM. Genes Dev. 2014 Feb 15;28(4):317-27. doi: 10.1101/gad.236794 PMID: 24532712.

Education

  • Postdoctorate, Molecular Pharmacology, Standford University Medical Center, USA, 1996 – 1999.
  • Ph.D., Molecular Biology, European Molecular Biology Lab, Germany, 1992 – 1996.
  • M.D., Università Degli Studi di Genova, Italy, 1985 – 1991.