Dana Devine

Contact Information
#4469, Life Sciences Centre
2350 Health Sciences Mall
Vancouver, BC, Canada V6T 1Z3
Tel 1-604-822-7270
Fax 1-604-822-7135
dana.devine@blood.ca
ddevine@pathology.ubc.ca

Current Positions

  • Chief Medical & Scientific Officer, Canadian Blood Services
  • Professor, Pathology and Laboratory Medicine, Medicine
  • Associate Member, Biochemistry and Molecular Biology, Medicine

Research Interests

The general subject areas of research expertise of this laboratory are platelet biology, complement biochemistry and blood coagulation. Our particular experimental focus in transfusion medicine is in the area of blood product processing and storage. Ongoing research projects include studies of the storage lesion of platelet concentrates and methods to improve the quality of stored platelet concentrates. Most recently, we have sought to apply leading edge technology to these research questions, in particular through the application of proteomics technology to investigations of blood products.

The research in the laboratory also includes a significant component of applied development work with projects related to practical solutions to issues arising in the manufacture of blood products including process control and quality enhancement through modification of production processes or through understanding more about the significance of the variability of donor characteristics. We have ongoing collaborations with other scientists in all of these areas as well as collaborations with companies working in the blood transfusion business.

Selected Publications

  1. Devine DV. Pathogen inactivation strategies to improve blood safety: let’s not throw pathogen-reduced platelets out with their bath water. JAMA Oncol. 2018 Feb 1. doi: 10.1001/jamaoncol.2017.4949. [Epub ahead of print].
  2.  Goldman M, W-Y Shih A, O’Brien SF, Devine D. Donor deferral policies for men who have sex with men: past, present and future. Vox Sang. 2017 Dec 13. doi: 10.1111/vox.12623. [Epub ahead of print]
  3.  Serrano K, Pambrun C, Levin E, Devine DV. Supernatant reduction of stored gamma-irradiated red blood cells minimizes potentially harmful substances present in transfusion aliquots for neonates. Transfusion. 2017 Dec;57(12):3009-3018.
  4. Germain M, Delage G, O’Brien SF, Grégoire Y, Fearon M, Devine D. Germain M, Delage G, O’Brien SF, Grégoire Y, Fearon M, Devine D. Mitigation of the threat posed to transfusion by donors traveling to Zika-affected areas: a Canadian risk-based approach. Transfusion. 2017 Oct;57(10):2463-2468.
  5. Chen D, Schubert P, Devine DV. Proteomic analysis of red blood cells from donors exhibiting high hemolysis demonstrates a reduction in membrane-associated proteins involved in the oxidative response. Transfusion. 2017 Sep;57(9):2248-2256.
  6.  Atkins CG, Schulze HG, Chen D, Devine DV, Blades MW, Turner RFB. Using Raman spectroscopy to assess hemoglobin oxygenation in red blood cell concentrate: an objective proxy for morphological index to gauge the quality of stored blood? Analyst. 2017 Jun 12;142(12):2199-2210.
  7. Schubert P, Culibrk B, Karwal S, Serrano K, Levin E, Yi Q, Thiele T, Greinacher A, Marschner S, Devine DV. Altered timing of riboflavin and ultraviolet light pathogen inactivation improves platelet in vitro quality. Transfusion. 2017 Aug;57(8):2026-2034.
  8. Devine DV. Implementation of pathogen inactivation technology: how to make the best decisions? Transfusion. 2017 May;57(5):1109-1111.
  9. Qadri SM, Chen D, Schubert P, Devine DV, Sheffield WP. Early γ-irradiation and subsequent storage of red cells in SAG-M additive solution potentiate energy imbalance, microvesiculation and susceptibility to stress-induced apoptotic cell death. Vox Sang. 2017 Jul;112(5):480-483.
  10. Chen Z, Schubert P, Bakkour S, Culibrk B, Busch MP, Devine DV. p38 mitogen-activated protein kinase regulates mitochondrial function and microvesicle release in riboflavin- and ultraviolet light-treated apheresis platelet concentrates. Transfusion. 2017 May;57(5):1199-1207.
  11.  Arbaeen AF, Schubert P, Serrano K, Carter CJ, Culibrk B, Devine DV. Pathogen inactivation treatment of plasma and platelet concentrates and their predicted functionality in massive transfusion protocols. Transfusion. 2017 May;57(5):1208-1217.
  12. van der Meer PF, Devine DV; Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Alternatives in blood operations when choosing non-DEHP bags. Vox Sang. 2017 Feb;112(2):183-184.
  13. Chen D, Schubert P, Devine DV. Identification of potential protein quality markers in pathogen inactivated and gamma-irradiated red cell concentrates. Proteomics Clin Appl. 2017 Jul;11(7-8).
  14. Qadri SM, Chen D, Schubert P, Perruzza DL, Bhakta V, Devine DV, Sheffield WP. Pathogen inactivation by riboflavin and ultraviolet light illumination accelerates the red blood cell storage lesion and promotes eryptosis. Transfusion. 2017 Mar;57(3):661-673.
  15. van der Meer PF, Couture C, Hervig T, Kruit G, Devine DV, de Korte D, Kerkhoffs JL. Experiences with semi-routine production of riboflavin and UV-B pathogen-inactivated platelet concentrates in three blood centres. Vox Sang. 2017 Jan;112(1):9-17.
  16.  Arbaeen AF, Serrano K, Levin E, Devine DV. Platelet concentrate functionality assessed by thromboelastography or rotational thromboelastometry. Transfusion. 2016 Nov;56(11):2790-2798.
  17. Klein-Bosgoed C, Schubert P, Devine DV. Riboflavin and ultraviolet illumination affects selected platelet mRNA transcript amounts differently. Transfusion. 2016 Sep;56(9):2286-95.
  18. Schubert P, Culibrk B, Karwal S, Goodrich RP, Devine DV. Protein translation occurs in platelet concentrates despite riboflavin/UV light pathogen inactivation treatment. Proteomics Clin Appl. 2016 Aug;10(8):839-50.
  19. Devine DV, Schubert P. Pathogen inactivation technologies: the advent of pathogen-reduced blood components to reduce blood safety risk. Hematol Oncol Clin North Am. 2016 Jun;30(3):609-17.
  20. Atkins CG, Buckley K, Chen D, Schulze HG, Devine DV, Blades MW, Turner RF. Raman spectroscopy as a novel tool for monitoring biochemical changes and inter-donor variability in stored red blood cell units. Analyst. 2016 May 23;141(11):3319-27.
  21. Schubert P, Coupland D, Nombalais M, M Walsh G, Devine DV. RhoA/ROCK signaling contributes to sex differences in the activation of human platelets. Thromb Res. 2016 Mar;139:50-5.
  22. Buckley K, Atkins CG, Chen D, Schulze HG, Devine DV, Blades MW, Turner RF. Non-invasive spectroscopy of transfusable red blood cells stored inside sealed plastic blood-bags. Analyst. 2016 Mar 7;141(5):1678-85.
  23. Serrano K, Levin E, Chen D, Hansen A, Turner TR, Kurach J, Reidel A, Boecker WF, Acker JP, Devine DV. An investigation of red blood cell concentrate quality during storage in paediatric-sized polyvinylchloride bags plasticized with alternatives to di-2-ethylhexyl phthalate (DEHP). Vox Sang. 2016 Apr;110(3):227-35.
  24. Johnson L, Schubert P, Tan S, Devine DV, Marks DC. Extended storage and glucose exhaustion are associated with apoptotic changes in platelets stored in additive solution. Transfusion. 2016 Feb;56(2):360-8.
  25. Spitalnik SL, Triulzi D, Devine DV, Dzik WH, Eder AF, Gernsheimer T, Josephson CD, Kor DJ, Luban NL, Roubinian NH, Mondoro T, Welniak LA, Zou S, Glynn S; State of the Science in Transfusion Medicine Working Groups. 2015 proceedings of the National Heart, Lung, and Blood Institute’s State of the Science in Transfusion Medicine symposium. Transfusion. 2015 Sep;55(9):2282-90.
  26. Williamson LM, Benjamin RJ, Devine DV, Katz LM, Pink J; Alliance of Blood Operators Medical Directors Group. A clinical governance framework for blood services. Vox Sang. 2015 May;108(4):378-86.
  27. Hansen AL, Kurach JD, Turner TR, Jenkins C, Busch MP, Norris PJ, Dugger J, Tomasulo PA, Devine DV, Acker JP. The effect of processing method on the in vitro characteristics of red blood cell products. Vox Sang. 2015 May;108(4):350-8.
  28. Schulze HG, Atkins CG, Devine DV, Blades MW, Turner RF. Fully automated decomposition of Raman spectra into individual Pearson’s type VII distributions applied to biological and biomedical samples. Appl Spectrosc. 2015 Jan;69(1):26-36.
  29. Chen Z, Schubert P, Culibrk B, Devine DV. p38MAPK is involved in apoptosis development in apheresis platelet concentrates after riboflavin and ultraviolet light treatment. Transfusion. 2015 Apr;55(4):848-57.
  30.  Schubert P, Culibrk B, Karwal S, Serrano K, Levin E, Bu D, Bhakta V, Sheffield WP, Goodrich RP, Devine DV. Whole blood treated with riboflavin and ultraviolet light: quality assessment of all blood components produced by the buffy coat method. Transfusion. 2015 Apr;55(4):815-23.
  31. Prudova A, Serrano K, Eckhard U, Fortelny N, Devine DV, Overall CM. TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage. Blood. 2014 Dec 18;124(26):e49-60.
  32. Goldman M, Lapierre D, Lemay L, Devine D, Sher G. Donor criteria for men who have sex with men: a Canadian perspective. Transfusion. 2014 Jul;54(7):1887-92.
  33. Prudent M, D’Alessandro A, Cazenave JP, Devine DV, Gachet C, Greinacher A, Lion N, Schubert P, Steil L, Thiele T, Tissot JD, Völker U, Zolla L. Proteome changes in platelets after pathogen inactivation–an interlaboratory consensus. Transfus Med Rev. 2014 Apr;28(2):72-83.
  34. Serrano K, Chen D, Hansen AL, Levin E, Turner TR, Kurach JD, Acker JP, Devine DV. The effect of timing of gamma-irradiation on hemolysis and potassium release in leukoreduced red cell concentrates stored in SAGM. Vox Sang. 2014 May;106(4):379-81.

Education

  • Postdoctoral (Hematology, Immunohematology) Duke University Medical Center, USA, 1987
  • Ph.D. (Immunology) Duke University, USA, 1986
  • M.Sc. (Biology, Marine Biology), Boston University, USA, 1981
  • B.Sc. (Biology) Boston University, USA, 1978

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