Dana Devine

Contact Information
Life Sciences Centre
#4469 – 2350 Health Sciences Mall
Vancouver, BC, Canada V6T 1Z3
Tel: 1-604-822-7270
Tel: 1-6048227853
Fax: 1-604-822-7135
Email: dana.devine@blood.ca
Email: ddevine@pathology.ubc.ca

Current Positions

  • Chief Medical & Scientific Officer, Canadian Blood Services.
  • Professor, Pathology and Laboratory Medicine, Medicine.
  • Associate Member, Biochemistry and Molecular Biology, Medicine.
  • Member, UBC Centre for Blood Research.

Research Interests

The general subject areas of research expertise of this laboratory are platelet biology, complement biochemistry and blood coagulation. Our particular experimental focus in transfusion medicine is in the area of blood product processing and storage. Ongoing research projects include studies of the storage lesion of platelet concentrates and methods to improve the quality of stored platelet concentrates. Most recently, we have sought to apply leading edge technology to these research questions, in particular through the application of proteomics technology to investigations of blood products.

The research in the laboratory also includes a significant component of applied development work with projects related to practical solutions to issues arising in the manufacture of blood products including process control and quality enhancement through modification of production processes or through understanding more about the significance of the variability of donor characteristics. We have ongoing collaborations with other scientists in all of these areas as well as collaborations with companies working in the blood transfusion business.

Selected Publications

  1. Spitalnik SJ, Devine DV. Translating red cell ‘omics’ into new perspectives in transfusion medicine: mining the gems in the data mountains. Transfusion. 2019 Jan;59(1):2-5.
  2. Vardaki MZ, Atkins CG, Schulze HG, Devine DV, Serrano K, Blades MW, Turner RFB. Raman spectroscopy of stored red blood cell concentrate within sealed transfusion blood bags. Analyst. 2018 Dec 3;143(24):6006-6013.
  3. Leach Bennett J, Devine DV. Risk-based decision making in transfusion medicine. Vox Sang. 2018 Nov;113(8):737-749.
  4. Schubert P, Johnson L, Marks DC, Devine DV. Ultraviolet-based pathogen inactivation systems: untangling the molecular targets activated in platelets.Front Med (Lausanne). 2018 May 7;5:129.
  5. Seheult JN, Shaz B, Bravo M, Croxon H, Devine D, Doncaster C, Field S, Flanagan P, Germain M, Grégoire Y, Kamel H, Karafin M, Kelting N, Lewis M, O’Brien C, Murphy MF, Rossmann S, Sayers M, Shinar E, Takanashi M, Titlestad K, Yazer MH; Biomedical Excellence for Safer Transfusions (BEST) Collaborative. Changes in plasma unit distributions to hospitals over a 10-year period. Transfusion. 2018 Apr;58(4):1012-1020.
  6. Devine DV. Pathogen inactivation strategies to improve blood safety: let’s not throw pathogen-reduced platelets out with their bath water. JAMA Oncol. 2018 Apr 1;4(4):458-459.
  7. Goldman M, W-Y Shih A, O’Brien SF, Devine D. Donor deferral policies for men who have sex with men: past, present and future.Vox Sang. 2018 Feb;113(2):95-103.
  8. Serrano K, Pambrun C, Levin E, Devine DV. Supernatant reduction of stored gamma-irradiated red blood cells minimizes potentially harmful substances present in transfusion aliquots for neonates. Transfusion. 2017 Dec;57(12):3009-3018.
  9. Germain M, Delage G, O’Brien SF, Grégoire Y, Fearon M, Devine D. Mitigation of the threat posed to transfusion by donors traveling to Zika-affected areas: a Canadian risk-based approach.Transfusion. 2017 Oct;57(10):2463-2468.
  10. Chen D, Schubert P, Devine DV. Proteomic analysis of red blood cells from donors exhibiting high hemolysis demonstrates a reduction in membrane-associated proteins involved in the oxidative response. Transfusion. 2017 Sep;57(9):2248-2256.
  11. Atkins CG, Schulze HG, Chen D, Devine DV, Blades MW, Turner RFB.Using Raman spectroscopy to assess hemoglobin oxygenation in red blood cell concentrate: an objective proxy for morphological index to gauge the quality of stored blood?  Analyst. 2017 Jun 12;142(12):2199-2210.
  12. Schubert P, Culibrk B, Karwal S, Serrano K, Levin E, Yi Q, Thiele T, Greinacher A, Marschner S, Devine DV. Altered timing of riboflavin and ultraviolet light pathogen inactivation improves platelet in vitro quality. Transfusion. 2017 Aug;57(8):2026-2034.
  13. Devine DV. Implementation of pathogen inactivation technology: how to make the best decisions? Transfusion. 2017 May;57(5):1109-1111.
  14. Qadri SM, Chen D, Schubert P, Devine DV, Sheffield WP. Early γ-irradiation and subsequent storage of red cells in SAG-M additive solution potentiate energy imbalance, microvesiculation and susceptibility to stress-induced apoptotic cell death. Vox Sang. 2017 Jul;112(5):480-483.
  15. Chen Z, Schubert P, Bakkour S, Culibrk B, Busch MP, Devine DV. p38 mitogen-activated protein kinase regulates mitochondrial function and microvesicle release in riboflavin- and ultraviolet light-treated apheresis platelet concentrates.  Transfusion. 2017 May;57(5):1199-1207.
  16. Arbaeen AF, Schubert P, Serrano K, Carter CJ, Culibrk B, Devine DV. Pathogen inactivation treatment of plasma and platelet concentrates and their predicted functionality in massive transfusion protocols. Transfusion. 2017 May;57(5):1208-1217.
  17. van der Meer PF, Devine DV. Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Alternatives in blood operations when choosing non-DEHP bags. Vox Sang. 2017 Feb;112(2):183-184.
  18. Chen D, Schubert P, Devine DV. Identification of potential protein quality markers in pathogen inactivated and gamma-irradiated red cell concentrates.Proteomics Clin Appl. 2017 Jul;11(7-8).
  19. Qadri SM, Chen D, Schubert P, Perruzza DL, Bhakta V, Devine DV, Sheffield WP. Pathogen inactivation by riboflavin and ultraviolet light illumination accelerates the red blood cell storage lesion and promotes eryptosis. Transfusion. 2017 Mar;57(3):661-673.
  20. van der Meer PF, Couture C, Hervig T, Kruit G, Devine DV, de Korte D, Kerkhoffs JL.Experiences with semi-routine production of riboflavin and UV-B pathogen-inactivated platelet concentrates in three blood centres. Vox Sang. 2017 Jan;112(1):9-17.
  21. Hadjesfandiari N, Schubert P, Fallah Toosi S, Chen Z, Culibrk B, Ramirez-Arcos S, Devine DV, Brooks DE. Effect of texture of platelet bags on bacterial and platelet adhesion. Transfusion. 2016 Nov;56(11):2808-2818.
  22. Arbaeen AF, Serrano K, Levin E, Devine DV. Platelet concentrate functionality assessed by thromboelastography or rotational thromboelastometry. Transfusion. 2016 Nov;56(11):2790-2798.
  23. Klein-Bosgoed C, Schubert P, Devine DV. Riboflavin and ultraviolet illumination affects selected platelet mRNA transcript amounts differently. Transfusion. 2016 Sep;56(9):2286-95.
  24. Yazer MH, Jackson B, Beckman N, Chesneau S, Bowler P, Delaney M, Devine D, Field S, Germain M, Murphy MF, Sayers M, Shaz B, Shinar E, Takanashi M, Vassallo R, Wickenden C, Yahalom V, Land K; Biomedical Excellence for Safer Transfusions (BEST) Collaborative. Changes in blood center red blood cell distributions in the era of patient blood management: the trends for collection (TFC) study. Transfusion. 2016 Aug;56(8):1965-73.
  25. Schubert P, Culibrk B, Karwal S, Goodrich RP, Devine DV. Protein translation occurs in platelet concentrates despite riboflavin/UV light pathogen inactivation treatment. Proteomics Clin Appl. 2016 Aug;10(8):839-50.
  26. Devine DV, Schubert P. Pathogen inactivation technologies: the advent of pathogen-reduced blood components to reduce blood safety risk. Hematol Oncol Clin North Am. 2016 Jun;30(3):609-17.
  27. Atkins CG, Buckley K, Chen D, Schulze HG, Devine DV, Blades MW, Turner RF. Raman spectroscopy as a novel tool for monitoring biochemical changes and inter-donor variability in stored red blood cell units. Analyst. 2016 May 23;141(11):3319-27.
  28. Bicalho B, Serrano K, Dos Santos Pereira A, Devine DV, Acker JP. Blood bag plasticizers influence red blood cell vesiculation rate without altering the lipid composition of the vesicles. Transfus Med Hemother. 2016 Jan;43(1):19-26.
  29. Schubert P, Coupland D, Nombalais M, M Walsh G, Devine DV. RhoA/ROCK signaling contributes to sex differences in the activation of human platelets. Thromb Res. 2016 Mar;139:50-5.
  30. Buckley K, Atkins CG, Chen D, Schulze HG, Devine DV, Blades MW, Turner RF.  Non-invasive spectroscopy of transfusable red blood cells stored inside sealed plastic blood-bags.  Analyst. 2016 Mar 7;141(5):1678-85.

Education

  • Postdoctoral (Hematology, Immunohematology) Duke University Medical Center, USA, 1987.
  • Ph.D. (Immunology) Duke University, USA, 1986.
  • M.Sc. (Biology, Marine Biology), Boston University, USA, 1981.
  • B.Sc. (Biology) Boston University, USA, 1978.