Christian Kastrup

Contact InformationChristian Kastrup
Michael Smith Laboratories
Room 211
2185 East Mall, Vancouver, BC, V6T 1Z4
Tel +1-604-827-3749
Lab +1-604-827-3750
Fax +1-604-822-2114
ckastrup@msl.ubc.ca
Lab Website: http://www.msl.ubc.ca/faculty/kastrup

Current Positions

  • Associate Professor, Michael Smith Laboratories
  • Associate Professor, Biochemistry and Molecular Biology
  • Associate Member,  Biomedical Engineering Program

Research Interests

Understanding the dynamics of biochemical networks is important for understanding life at the systems level and has practical implications for Medicine, Engineering, Biology, and Chemistry. The complex network of hemostasis consists of over 100 coupled reactions and has the death-defying function of regulating blood coagulation. Research in my laboratory focuses on three problems related to blood coagulation: i) understanding the biophysical mechanisms by which blood clots form and degrade, ii) controlling these processes to eliminate unwanted coagulation, and iii) using coagulation as a scaffold for delivering therapeutics to diseased vasculature. This research lies at the interface of Chemical Biology, Bioengineering and Medicine. The techniques we use include microfluidics, reconstituted protein systems, biomaterial synthesis, numerical simulations, and disease models of coagulation and atherosclerosis.

Selected Publications

  1. Yeon JH*, Mazinani N*, Schlappi T, Donovan A, Smith S, Baylis JR*, Chan KYT*, Kudela D, Stucky G, Ismagilov RF, Liu Y, Morrissey JH, Kastrup CJ, “Localization of Short-Chain Polyphosphate Enhances its Ability to Clot Flowing Blood Plasma”, Scientific Reports, 2017, 42119. (SA) (IF 5.2)
  2. Pompano R, Kastrup CJ, Ismagilov RF, “Understanding spatial effects in nonlinear biochemical networks: patchy switching“, Annual Review of Biochemistry, 2017 (86):333-356 (CA) (IF 30.3)
  3. Baylis JR*, Finkelstein A*, Macias-Valle L, Manji J, Lee M, Levchenko E, Okpaleke C, AL-Salihi S, Javer AR**, Kastrup CJ**, “Rapid hemostasis in a sheep model using particles that propel thrombin and tranexamic acid”, Laryngoscope, 2017 (127):787-793. **equal contribution. (SA) (IF 2.0)
  4. Pryzdial E, Meixner S, Talbot K, EltringhamSmith L, Baylis J, Kastrup C, Sheffield W, “Thrombolysis by Chemically Modified Coagulation Factor Xa”, Journal of Thrombosis and Haemostasis, 2016 (14):1844-54. (CA) (IF 5.7)
  5. Baylis JR, St. John AE, Wang X, Lim EB, Statz ML, Chien D, Stern SA, Simonson E, Liggins RT, White NJ, Kastrup CJ, “Self-Propelled Dressings Containing Thrombin and Tranexamic Acid Improve Short-Term Survival in a Swine Model of Lethal Junctional Hemorrhage”, Shock, 2016 (46-S1):123-8. (SA) (IF 3.1)
  6. Baylis JR, Chan KYT, Kastrup CJ, “Halting Hemorrhage with Self-Propelling Particles and Local Drug Delivery”, Thrombosis Research, 2016 (141):S36-39. (SA) (IF 2.4)
  7. Chan KYT, Zhao C, Boschman J, Kastrup CJ, “Adhesion of Blood Clots can be Enhanced when Copolymerized with a Macromer that is Crosslinked by Coagulation Factor XIIIa”, Biomacromolecules, 2016 (17):2248-52. (SA) (IF 5.8)
  8. Chan V*, Novakowski SK*, Law S, Klein-Bosgoed C, Kastrup CJ, “Controlled Transcription of Exogenous mRNA in Platelets Using Protocells”, Angewandte Chemie International Edition, 2015:13590-13593. (SA) (IF 11.3)
  9. Hur WS, Mazinani N, Lu XJD, Britton HM, Byrnes JR, Wolberg AS, Kastrup CJ, “Coagulation Factor XIIIa is Inactivated by Plasmin”, Blood, 2015: 2329 – 2337. (SA) (IF 10.5)
  10. Baylis JR, Yeon JH, Thomson MH, Kazerooni A, Wang X, St. John AE, Lim EB, Chien D, Lee A, Zhang JQ, Piret JM, Machan LS, Burke TF, White NJ, Kastrup CJ, “Self-Propelling Particles that Transport Cargo Through Flowing Blood and Halt Hemorrhaging”, Science Advances, 2015:e1500379, 1-8. (SA) (No impact factor has been assigned yet, as this is a new journal. It is a sub-journal of Science/AAAS, and is highly selective, currently publishing fewer papers than Science itself.)
  11. Yeon JH, Chan KYT, Wong TC, Chan K, Sutherland MR, Ismagilov RF, Pryzdial ELG, Kastrup CJ, “A Biochemical Network can Control Formation of a Synthetic Material by Sensing Numerous Specific Stimuli”, Scientific Reports, 2015, 10274: 1-8. (SA) (IF 5.6)
  12. Kretschmer M, Reiner E, Hu G, Tam N, Oliveira DL, Caza M, Yeon JH, Kim J, Kastrup CJ, Jung WH, Kronstad JW, “Defects in Phosphate Acquisition and Storage Influence the Virulence of Cryptococcus neoformans”, Infection and Immunity, 2014: 2697-2712. (CA) (IF 4.1)
  13. Kastrup CJ, Nahrendorf M, Figueiredo JL, Lee H, Kambhampati S, Lee T, Cho SW, Gorbatov R, Iwamoto Y, Dang TT, Dutta P, Yeon JH, Cheng H, Pritchard CD, Vegas AJ, Siegel CD, Macdougall S, Okonkwo M, Thai A, Stone JR, Coury AJ, Weissleder R, Langer R, Anderson DG. Painting blood vessels and atherosclerotic plaques with an adhesive drug depot. Proc Natl Acad Sci U S A. 2012 Dec 11.
  14. Cheng H, Byrska-Bishop M, Zhang CT, Kastrup CJ, Hwang NS, Tai AK, Lee WW, Xu X, Nahrendorf M, Langer R, Anderson DG. Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics. Biomaterials. 2012 Jul;33(20):5004-12.
  15. H. Cheng, C.J. Kastrup, R. Ramanathan, D.J. Siegwart, M.L. Ma, S.R. Bogatyrev, Q.B. Xu, K.A. Whitehead, R. Langer,D.G. Anderson, “Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery”, ACS Nano, 2010 (4): 625-631.
  16. F. Shen, C.J. Kastrup, R.R. Pompano, R.F. Ismagilov, “Confinement Regulates Complex Biochemical Networks: Initiation of Blood Clotting by “Diffusion Acting”, Biophysical Journal, 2009 (97): 2137-2135.
  17. C.J. Kastrup, J.Q. Boedicker, A.P. Pomerantsev, M. Moayeri, Y. Bian, R.R. Pompano, T.R. Kline, F. Shen, W.-J. Tang, S.H. Leppla, R.F. Ismagilov, “Spatial Localization of Bacteria Controls Initiation of Blood Coagulation by “Quorum Acting”, Nature Chemical Biology, 2008 (4) 742-750.
  18. F. Shen, C.J. Kastrup, Y. Liu, R.F. Ismagilov, “Threshold Response of Initiation of Blood Coagulation by Tissue Factor in Patterned Microfluidic Capillaries is Controlled by Shear Rate”, Arteriosclerosis Thrombosis and Vascular Biology, 2008 (28): 2035-2041.
  19. C.J. Kastrup, M.K. Runyon, E.M. Lucchetta, R.F. Ismagilov, “Using Chemistry and Microfluidics to Understand the Spatial Dynamics of Complex Biological Networks” Accounts of Chemical Research, 2007 (41): 549-558.
  20. M.K. Runyon, C.J. Kastrup, B. Johnson-Kerner, T.G. Van Ha, R.F. Ismagilov, “The Effects of Shear Rate on Propagation of Blood Clotting Determined Using Microfluidics and Numerical Simulations” Journal of the American Chemical Society, 2008 (130): 3458-3464.
  21. C.J. Kastrup, F. Shen, R.F. Ismagilov, “Characterization of the Threshold Response of Initiation of Blood Clotting to Stimulus Patch Size,” Biophysical Journal, 2007 (93): 2969-2977.
  22. C.J. Kastrup, R.F. Ismagilov, “A physical-organic mechanistic approach to understanding the complex reactionnetwork of hemostasis (blood clotting),” Journal of Physical Organic Chemistry, 2007 (20): 711-715.
  23. M.K. Runyon, B. Johnson-Kerner, C.J. Kastrup, T.G. Van Ha, R.F. Ismagilov, “Simple Chemistry Identifies Mechanism for Localization of Blood Clots in Complex Network of Hemostasis,” Journal of the American Chemical Society, 2007 (129): 7014-7015.
  24. C.J. Kastrup, F.Shen, R.F. Ismagilov, Response to shape emerges in a complex biochemical network and its simple chemical analogue. Angewandte Chemie International Edition, 2007 (46): 3660-3662.

Education

  • Ph.D. (2008) University of Chicago
  • Postdoctoral fellow (2008-2011) Massachusetts Institute of Technology