Christian Kastrup

Contact InformationChristian Kastrup
Michael Smith Laboratories
Room 211
2185 East Mall, Vancouver, BC, V6T 1Z4
Tel +1-604-827-3749
Lab +1-604-827-3750
Fax +1-604-822-2114
ckastrup@msl.ubc.ca
Lab Website: http://www.msl.ubc.ca/faculty/kastrup

Current Positions

  • Assistant Professor, Michael Smith Laboratories
  • Assistant Professor, Biochemistry and Molecular Biology
  • Associate Member,  Biomedical Engineering Program

Research Interests

Understanding the dynamics of biochemical networks is important for understanding life at the systems level and has practical implications for Medicine, Engineering, Biology, and Chemistry. The complex network of hemostasis consists of over 100 coupled reactions and has the death-defying function of regulating blood coagulation. Research in my laboratory focuses on three problems related to blood coagulation: i) understanding the biophysical mechanisms by which blood clots form and degrade, ii) controlling these processes to eliminate unwanted coagulation, and iii) using coagulation as a scaffold for delivering therapeutics to diseased vasculature. This research lies at the interface of Chemical Biology, Bioengineering and Medicine. The techniques we use include microfluidics, reconstituted protein systems, biomaterial synthesis, numerical simulations, and disease models of coagulation and atherosclerosis.

Publications

  1. Kastrup CJ, Nahrendorf M, Figueiredo JL, Lee H, Kambhampati S, Lee T, Cho SW, Gorbatov R, Iwamoto Y, Dang TT, Dutta P, Yeon JH, Cheng H, Pritchard CD, Vegas AJ, Siegel CD, Macdougall S, Okonkwo M, Thai A, Stone JR, Coury AJ, Weissleder R, Langer R, Anderson DG. Painting blood vessels and atherosclerotic plaques with an adhesive drug depot. Proc Natl Acad Sci U S A. 2012 Dec 11.
  2. Cheng H, Byrska-Bishop M, Zhang CT, Kastrup CJ, Hwang NS, Tai AK, Lee WW, Xu X, Nahrendorf M, Langer R, Anderson DG. Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics. Biomaterials. 2012 Jul;33(20):5004-12.
  3. H. Cheng, C.J. Kastrup, R. Ramanathan, D.J. Siegwart, M.L. Ma, S.R. Bogatyrev, Q.B. Xu, K.A. Whitehead, R. Langer,D.G. Anderson, “Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery”, ACS Nano, 2010 (4): 625-631.
  4. F. Shen, C.J. Kastrup, R.R. Pompano, R.F. Ismagilov, “Confinement Regulates Complex Biochemical Networks: Initiation of Blood Clotting by “Diffusion Acting”, Biophysical Journal, 2009 (97): 2137-2135.
  5. C.J. Kastrup, J.Q. Boedicker, A.P. Pomerantsev, M. Moayeri, Y. Bian, R.R. Pompano, T.R. Kline, F. Shen, W.-J. Tang, S.H. Leppla, R.F. Ismagilov, “Spatial Localization of Bacteria Controls Initiation of Blood Coagulation by “Quorum Acting”, Nature Chemical Biology, 2008 (4) 742-750.
  6. F. Shen, C.J. Kastrup, Y. Liu, R.F. Ismagilov, “Threshold Response of Initiation of Blood Coagulation by Tissue Factor in Patterned Microfluidic Capillaries is Controlled by Shear Rate”, Arteriosclerosis Thrombosis and Vascular Biology, 2008 (28): 2035-2041.
  7. C.J. Kastrup, M.K. Runyon, E.M. Lucchetta, R.F. Ismagilov, “Using Chemistry and Microfluidics to Understand the Spatial Dynamics of Complex Biological Networks” Accounts of Chemical Research, 2007 (41): 549-558.
  8. M.K. Runyon, C.J. Kastrup, B. Johnson-Kerner, T.G. Van Ha, R.F. Ismagilov, “The Effects of Shear Rate on Propagation of Blood Clotting Determined Using Microfluidics and Numerical Simulations” Journal of the American Chemical Society, 2008 (130): 3458-3464.
  9. C.J. Kastrup, F. Shen, R.F. Ismagilov, “Characterization of the Threshold Response of Initiation of Blood Clotting to Stimulus Patch Size,” Biophysical Journal, 2007 (93): 2969-2977.
  10. C.J. Kastrup, R.F. Ismagilov, “A physical-organic mechanistic approach to understanding the complex reactionnetwork of hemostasis (blood clotting),” Journal of Physical Organic Chemistry, 2007 (20): 711-715.
  11. M.K. Runyon, B. Johnson-Kerner, C.J. Kastrup, T.G. Van Ha, R.F. Ismagilov, “Simple Chemistry Identifies Mechanism for Localization of Blood Clots in Complex Network of Hemostasis,” Journal of the American Chemical Society, 2007 (129): 7014-7015.
  12. C.J. Kastrup, F.Shen, R.F. Ismagilov, Response to shape emerges in a complex biochemical network and its simple chemical analogue. Angewandte Chemie International Edition, 2007 (46): 3660-3662.
  13. C.J. Kastrup, M.K. Runyon, F. Shen, R.F. Ismagilov, “Modular Chemical Mechanism Predicts Spatiotemporal Dynamics of Initiation in the Complex Network of Hemostasis,” Proceedings of the National Academy of Sciences, 2006 (103): 15747-15752.
  14. C.J. Kastrup, S.V. Oldfield, H.S. Rzepa, “The aromaticity and Möbius characteristics of carbeno[8] heteroannulenes and triplet state annulenes,” Chemical Communications, 2002 (6): 642-643.
  15. C.J. Kastrup, S.V. Oldfield, H.S. Rzepa, “An ab initio computational study of monodentate palladium ligand complexes with Mobius-aromatic chiral character,” Journal of the Chemical Society-Dalton Transactions, 2002 (12): 2421-2422.
  16. W.L. Karney, C.J. Kastrup, S.V. Oldfield, H.S. Rzepa, “Möbius aromatic forms of 8-pi electron heteropine,” Journal of the Chemical Society-Perkin Transactions 2, 2002 (3): 388-392.

Education

  • Ph.D. (2008) University of Chicago
  • Postdoctoral fellow (2008-2011) Massachusetts Institute of Technology

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