Publications

A Novel Microfluidic Device to Aid in the Search for Red Blood Cell “Super-storers”

A Novel Microfluidic Device to Aid in the Search for Red Blood Cell “Super-storers”

Donated red blood cell units are a vital component of patient care, supporting patients with a wide variety of disorders.

Host Tissue Factor on the Virus Envelope – A New Antiviral Target?

Host Tissue Factor on the Virus Envelope – A New Antiviral Target?

Viruses are small genetic bundles that hijack the metabolic processes of infected cells and can make us sick. One type of virus, called “enveloped viruses”, includes influenza, human immunodeficiency virus (HIV) and herpes simplex virus 1 (HSV-1).

Figure 1: Vasculature of mice imaged using fluorescence microscopy. Wild-type (PodxlF/F) and Podocalyxin knockout (PodxlTie2DEC) mice were treated with lipopolysaccharide (LPS). Vasculature was imaged using 649-LEL and permeability was assessed using Texas red (TR) labelled 70-kD dextran (TR-DEX70). The authors describe the permeability as ‘dextran clouds’ in the podocalyxin knockout mice, signifying leakage of dextran outside of the blood vessel. Modified from Figure 4B from Cait et al. (2019).

A new player in blood-brain-barrier integrity

Podocalyxin (Podxl) is a protein primarily expressed on the inner surface of blood vessels and specialized kidney cells called podocytes. Although Podxl plays a critical role in kidney development and function, its purpose in blood vessels has remained cryptic.

Metaling with Chelation Therapy: Reducing Transfusion-Associated Iron Toxicity with Conjugated Drugs

Metaling with Chelation Therapy: Reducing Transfusion-Associated Iron Toxicity with Conjugated Drugs

Beta-thalassemias are a group of inherited blood disorders caused by a decrease in beta hemoglobin chains that can result in severe anemia, reduced oxygen supply to tissues, failure to thrive, and death.

Dampening the Inflammatory Response to P. aeruginosa Infection using a Synthetic Immunomodulatory Peptide

Dampening the Inflammatory Response to P. aeruginosa Infection using a Synthetic Immunomodulatory Peptide

Antibiotic resistance and the lack of novel antibiotics pose a real threat to health, and therefore new solutions to fight resistant bacteria are required.

Self-propelled Hemostatic Particles Find a New Home in Gauze and Spray Cartridges

Self-propelled Hemostatic Particles Find a New Home in Gauze and Spray Cartridges

Self-propelled particles—What started as a “wouldn’t that be cool” idea has become a real technology that has gained the support of many groups that hope to some day see this product, on the front of both military and civilian lines, saving lives.

Walking the Tightrope

Walking the Tightrope

Imagine, you are walking on a tightrope. If you fall to one side of this narrow line, zombies are waiting to eat you up. On the other side, it is a fall into a crazy deep canyon.

Can Dysfunctional Clotting Contribute to Neurological Disorders?

Can Dysfunctional Clotting Contribute to Neurological Disorders?

Alzheimer’s disease is a devastating neurological disorder with no known cure. Characterized by gradual cognitive decline, its effects are felt throughout Canada. Over half a million Canadians are living with dementia, and Alzheimer’s disease is a major contributor to this number.

New Anticoagulants Enhance “Clot-busting” Ability of the “Clot-former” Factor Xa

New Anticoagulants Enhance “Clot-busting” Ability of the “Clot-former” Factor Xa

If you, loved ones or friends suffer from diseases that may involve abnormal blood clotting, such as heart attack, stroke, atherosclerosis, deep vein thrombosis, pulmonary embolism or even cancer, commercials on “blood thinners” (anticoagulants) may catch your attention more than other drugs while watching your favourite TV show.

Thrombomodulin: Old Protein with New Functions and Hope

Thrombomodulin: Old Protein with New Functions and Hope

As its name suggests, thrombomodulin (TM) modulates thrombin activity. The traditional role of TM is to vastly accelerate production of activated protein C from its zymogen by thrombin.