Publications

UBC researcher helps map the human proteome

UBC researcher helps map the human proteome

With 90 per cent of the proteins in the human body now mapped, Overall says scientists have a deeper understanding of how individual proteins interact to influence human health, providing insights into disease prevention and individualized medicine.

Fast and Furious: Targeting “nitro(gen) boosts” in a deadly bacterium for next-generation antimicrobials

Fast and Furious: Targeting “nitro(gen) boosts” in a deadly bacterium for next-generation antimicrobials

What if bacteria also had the ability to use nitrogen for a “boost”? Alford et al. recently examined the role of a two-component system called NtrBC in Pseudomonas aeruginosa.

Coagulation Going Viral: Wisdom to Draw from Herpes Simplex Virus-1 Investigation

Coagulation Going Viral: Wisdom to Draw from Herpes Simplex Virus-1 Investigation

Cardio- and cerebro-vascular diseases remain the leading causes of death worldwide.

Soil in wounds can help stem deadly bleeding

Soil in wounds can help stem deadly bleeding

New UBC research shows for the first time that soil silicates—the most abundant material on the Earth’s crust—play a key role in blood clotting.

Connecting the immunological dots: (Ca2+)n we do it?

Connecting the immunological dots: (Ca2+)n we do it?

When we think about how lymphocytes work, we tend to think that antigen presentation and signaling are the be-all and end-all of immune system activation and function.

A Novel Microfluidic Device to Aid in the Search for Red Blood Cell “Super-storers”

A Novel Microfluidic Device to Aid in the Search for Red Blood Cell “Super-storers”

Donated red blood cell units are a vital component of patient care, supporting patients with a wide variety of disorders.

Host Tissue Factor on the Virus Envelope – A New Antiviral Target?

Host Tissue Factor on the Virus Envelope – A New Antiviral Target?

Viruses are small genetic bundles that hijack the metabolic processes of infected cells and can make us sick. One type of virus, called “enveloped viruses”, includes influenza, human immunodeficiency virus (HIV) and herpes simplex virus 1 (HSV-1).

Figure 1: Vasculature of mice imaged using fluorescence microscopy. Wild-type (PodxlF/F) and Podocalyxin knockout (PodxlTie2DEC) mice were treated with lipopolysaccharide (LPS). Vasculature was imaged using 649-LEL and permeability was assessed using Texas red (TR) labelled 70-kD dextran (TR-DEX70). The authors describe the permeability as ‘dextran clouds’ in the podocalyxin knockout mice, signifying leakage of dextran outside of the blood vessel. Modified from Figure 4B from Cait et al. (2019).

A new player in blood-brain-barrier integrity

Podocalyxin (Podxl) is a protein primarily expressed on the inner surface of blood vessels and specialized kidney cells called podocytes. Although Podxl plays a critical role in kidney development and function, its purpose in blood vessels has remained cryptic.

Metaling with Chelation Therapy: Reducing Transfusion-Associated Iron Toxicity with Conjugated Drugs

Metaling with Chelation Therapy: Reducing Transfusion-Associated Iron Toxicity with Conjugated Drugs

Beta-thalassemias are a group of inherited blood disorders caused by a decrease in beta hemoglobin chains that can result in severe anemia, reduced oxygen supply to tissues, failure to thrive, and death.

Dampening the Inflammatory Response to P. aeruginosa Infection using a Synthetic Immunomodulatory Peptide

Dampening the Inflammatory Response to P. aeruginosa Infection using a Synthetic Immunomodulatory Peptide

Antibiotic resistance and the lack of novel antibiotics pose a real threat to health, and therefore new solutions to fight resistant bacteria are required.