Publications

Dampening the Inflammatory Response to P. aeruginosa Infection using a Synthetic Immunomodulatory Peptide

Dampening the Inflammatory Response to P. aeruginosa Infection using a Synthetic Immunomodulatory Peptide

Antibiotic resistance and the lack of novel antibiotics pose a real threat to health, and therefore new solutions to fight resistant bacteria are required.

Self-propelled Hemostatic Particles Find a New Home in Gauze and Spray Cartridges

Self-propelled Hemostatic Particles Find a New Home in Gauze and Spray Cartridges

Self-propelled particles—What started as a “wouldn’t that be cool” idea has become a real technology that has gained the support of many groups that hope to some day see this product, on the front of both military and civilian lines, saving lives.

Walking the Tightrope

Walking the Tightrope

Imagine, you are walking on a tightrope. If you fall to one side of this narrow line, zombies are waiting to eat you up. On the other side, it is a fall into a crazy deep canyon.

Can Dysfunctional Clotting Contribute to Neurological Disorders?

Can Dysfunctional Clotting Contribute to Neurological Disorders?

Alzheimer’s disease is a devastating neurological disorder with no known cure. Characterized by gradual cognitive decline, its effects are felt throughout Canada. Over half a million Canadians are living with dementia, and Alzheimer’s disease is a major contributor to this number.

New Anticoagulants Enhance “Clot-busting” Ability of the “Clot-former” Factor Xa

New Anticoagulants Enhance “Clot-busting” Ability of the “Clot-former” Factor Xa

If you, loved ones or friends suffer from diseases that may involve abnormal blood clotting, such as heart attack, stroke, atherosclerosis, deep vein thrombosis, pulmonary embolism or even cancer, commercials on “blood thinners” (anticoagulants) may catch your attention more than other drugs while watching your favourite TV show.

Thrombomodulin: Old Protein with New Functions and Hope

Thrombomodulin: Old Protein with New Functions and Hope

As its name suggests, thrombomodulin (TM) modulates thrombin activity. The traditional role of TM is to vastly accelerate production of activated protein C from its zymogen by thrombin.

From Computers to Clinics: Advances in Designing Polyphosphate Inhibitors as Novel Anti-thrombotics

From Computers to Clinics: Advances in Designing Polyphosphate Inhibitors as Novel Anti-thrombotics

Thrombosis, the formation of a potentially deadly blood clot, remains one of the leading causes of death and disability worldwide. Once formed, clots can slow or obstruct normal blood flow, leading to damage to surrounding tissue.

Proteases can be a turn-on, or a turn-off. Or… A Protease-mediated Switch Controls the Transition from Proinflammatory (M1) to Repair (M2) Macrophages

Proteases can be a turn-on, or a turn-off. Or… A Protease-mediated Switch Controls the Transition from Proinflammatory (M1) to Repair (M2) Macrophages

Chronic inflammatory & autoimmune diseases affect many Canadians, and yet the mechanisms behind such conditions are not fully understood and there is no cure available.

Lipid carrier synthesis and recycling. (i) Structure of UppP (green) in complex with structural lipid and substrate mimic, monoolein (pink) (E. coli, 6CB2). (ii) Proposed reaction mechanism for UppP mediated dephosphorylation of C55PP. (iii) Schematic representation of proposed UppP phosphatase-couple lipid flippase activity. (iv) Twofold symmetry axis of the UppP dimer (black) and twofold pseudosymmetry axes of each monomer (grey).

Paradigm Shifts in Cell Wall Biogenesis Understanding

Antibiotic resistance has become a major issue in recent years, and is believed to be directly linked to the livestock industry which accounts for ~80% of antibiotic use in North America. Frighteningly, this is expected to rise by nearly 70% globally by 2030.

Gene-trap Mutagenesis Identifies a Crucial Role for a Cryptic Member of the ABC Superfamily

Gene-trap Mutagenesis Identifies a Crucial Role for a Cryptic Member of the ABC Superfamily

The ATP-binding cassette (ABC) super-family of proteins is one of the largest families of proteins to have representatives in all living organisms from prokaryotes to humans.