Publications

From Computers to Clinics: Advances in Designing Polyphosphate Inhibitors as Novel Anti-thrombotics

From Computers to Clinics: Advances in Designing Polyphosphate Inhibitors as Novel Anti-thrombotics

Thrombosis, the formation of a potentially deadly blood clot, remains one of the leading causes of death and disability worldwide. Once formed, clots can slow or obstruct normal blood flow, leading to damage to surrounding tissue.

Proteases can be a turn-on, or a turn-off. Or… A Protease-mediated Switch Controls the Transition from Proinflammatory (M1) to Repair (M2) Macrophages

Proteases can be a turn-on, or a turn-off. Or… A Protease-mediated Switch Controls the Transition from Proinflammatory (M1) to Repair (M2) Macrophages

Chronic inflammatory & autoimmune diseases affect many Canadians, and yet the mechanisms behind such conditions are not fully understood and there is no cure available.

Lipid carrier synthesis and recycling. (i) Structure of UppP (green) in complex with structural lipid and substrate mimic, monoolein (pink) (E. coli, 6CB2). (ii) Proposed reaction mechanism for UppP mediated dephosphorylation of C55PP. (iii) Schematic representation of proposed UppP phosphatase-couple lipid flippase activity. (iv) Twofold symmetry axis of the UppP dimer (black) and twofold pseudosymmetry axes of each monomer (grey).

Paradigm Shifts in Cell Wall Biogenesis Understanding

Antibiotic resistance has become a major issue in recent years, and is believed to be directly linked to the livestock industry which accounts for ~80% of antibiotic use in North America. Frighteningly, this is expected to rise by nearly 70% globally by 2030.

Gene-trap Mutagenesis Identifies a Crucial Role for a Cryptic Member of the ABC Superfamily

Gene-trap Mutagenesis Identifies a Crucial Role for a Cryptic Member of the ABC Superfamily

The ATP-binding cassette (ABC) super-family of proteins is one of the largest families of proteins to have representatives in all living organisms from prokaryotes to humans.

McNagny Lab Uncovers a New Protective Role for an Old Protein During Lung Repair

McNagny Lab Uncovers a New Protective Role for an Old Protein During Lung Repair

Members of the McNagny lab at the Centre for Blood Research focus their efforts on understanding CD34, a cell surface protein typically used as a marker for progenitors of blood cells. In their paper, Bernard Lo of the McNagny lab, and collaborators, investigated the role of CD34 in lung disease using mouse models of acute lung injury.

Feeding the Spore: A Molecular Structure of the SpoIIIAG Channel from Bacillus subtilis

Feeding the Spore: A Molecular Structure of the SpoIIIAG Channel from Bacillus subtilis

Natalie Zeytuni and colleagues in the Strynadka Lab at the CBR have determined the structure of SpoIIIAG, a key protein contributed by the mother cell of the sporulation channel from the Gram-positive bacterium, Bacillus subtilis.

Rational Design of Universal Heparin Reversal Agent (UHRA) Makes it a Highly Specific Antidote to Heparins

Rational Design of Universal Heparin Reversal Agent (UHRA) Makes it a Highly Specific Antidote to Heparins

The only FDA approved heparin antidote is protamine, but it has many limitations. In a recent paper, Dr. Kalathottukaren and team discuss how the rational design of UHRA makes it a better antidote to heparins compared to protamine.

Look! Down in the petri dish! It’s a Superplatelet!

Look! Down in the petri dish! It’s a Superplatelet!

Dr. Kastrup, a scientist in UBC’s Michael Smith Laboratories and the Centre for Blood Research, has developed a potential strategy for making the coagulation process more resilient. If it’s proven to work in clinical situations, “superplatelets” might become a standard part of emergency department supplies, along with bandages, oxygen, and saline.

Hancock Lab Demonstrates the Role of a Bacterial Starvation Response in Wound Infections

Hancock Lab Demonstrates the Role of a Bacterial Starvation Response in Wound Infections

When bacteria are starved or stressed, they can become resistant to antibiotics. In Frontiers in Microbiology, members of the Hancock lab explored the importance of a specific stress response and its mechanism in infection.

Innate Defence Regulator Peptides: An Anti-Inflammatory Therapy?

Innate Defence Regulator Peptides: An Anti-Inflammatory Therapy?

Inflammation is an important component of our body’s defence system, but excessive or inappropriate inflammation is the main cause behind many human diseases. In a recent publication, Bing Catherine Wu and Amy Lee of the Hancock Lab identify a new potential anti-inflammatory therapy: Innate Defence Regulator (IDR) peptides.