Hongshen Ma

Contact Information
Life Sciences Centre
2350 Health Sciences Mall
Vancouver, BC, Canada V6T 1Z3
Tel 604.827.4703
Fax 1-604-822-7135
hongma@mech.ubc.ca

 

 

Current Positions

  • Associate Professor, Department of Mechanical Engineering
  • Associate Professor, School of Biomedical Engineering
  • Associate member, Department of Urologic Sciences
  • Senior Research Scientist, Vancouver Prostate Centre, Vancouver General Hospital
  • Associate member, Department of Pathology and Laboratory Medicine

Research Interests

The overarching goal of our research is the development of new technologies for medical research and treatment. Our work is enabled by advances in fabrication, measurement, and computation across a wide range of domains and length scales. Our core capabilities include microfabrication, microfluidics, instrumentation and automation, data analytics, and product development. Current research areas include 1) the development of new technologies for cell sorting, cell biomechanics, single cell sequencing, and cell migration and chemotaxis; as well as 2) the application of these technologies to study circulating tumor cells, personalize cancer therapies, assess blood quality, and expedite antimalarial drug development.

Selected Publications

  1. Guo Q, Matthews K, Islamzada E, Duffy SP, Deng X, Ma H, Deformability based Cell Sorting Enabling Phenotypic Fractionation of Leukocytes, Scientific Reports, 7, 6627, 2017.
  2. Matthews K, Duffy SP, Myrand-Lapierre M, Ang RR, Li L, Scott MD, Ma H, Microfluidic analysis of red blood cell deformability as a means to assess hemin-induced oxidative stress resulting from Plasmodium falciparum intraerythrocytic parasitism, Integrative Biology, 9, 519-528, 2017.
  3. Park ES, Jin C, Guo Q, Ang RR, Duffy SP, Matthews K, Azad A, Abdi H, Todenhöfer T, Chi KN, Black PC, Ma H, Continuous Flow Deformability-Based Separation of Circulating Tumor Cells Using Microfluidic Ratchets, Small, 12(14), 1909-1919, 2016.
  4. Guo Q, Duffy SP, Matthews K, Deng X, Santoso AT, Islamzada E, Ma H, Deformability based Sorting of Red Blood Cells Improves Diagnostic Sensitivity for Malaria Caused by Plasmodium Falciparum, Lab on a Chip (Communication), 16, 645-654, 2016.
  5. Deng X, Duffy SP, Myrand-Lapierre M, Matthews K, Santoso AT, Du Y, Ryan KS, Ma H, Reduced Deformability of Parasitized Red Blood Cells as a Biomarker for Antimalarial Drug Efficacy, Malaria Journal, 14(1), 428, 2015.
  6. Santoso AT, Deng X, Lee JH, Matthews K, Duffy SP, Islamzada E, Myrand-Lapierre M, McFaul SM, Ma H, Microfluidic Cell-phoresis Enabling High-throughput Analysis of Red Blood Cell Deformability and Biophysical Screening of Antimalarial Drugs, Lab on a Chip, 15(23), 4451-4460, 2015.
  7. Park S, Ang RR, Bazov J, Chi KN, Black PC, Ma H, Morphological Differences Between Circulating Tumour Cells from Prostate Cancer Patients and Cultured Prostate Cancer Cells, PLoS ONE, 9(1), e85264, 2014.
  8. Guo Q, Park S, Ma H, Microfluidic micropipette aspiration for measuring the deformability of single cells, Lab on a Chip, 12(15), 2687-2695, 2012.
  9. McFaul SM, Lin BK, Ma H, Cell separation based on size and deformability using microfluidic funnel ratchets, Lab on a Chip, 12 (13), 2369-2376, 2012.
  10. Guo Q, Reiling SJ, Rohrbach P, Ma H, Microfluidic Biomechanical Assay for Red Blood Cells Parasitized by Plasmodium falciparum, Lab on a Chip, 12 (6), 1143-1150, 2012.

Education

  • Postdoctoral Scientist, Mechanical Engineering, Massachusetts Institute of Technology
  • Ph.D., Electrical Engineering, Massachusetts Institute of Technology
  • M.S., Media Laboratory, Massachusetts Institute of Technology
  • B.A.Sc., Engineering Physics, University of British Columbia