Elisabeth Maurer-Spurej

Contact InformationElisabeth Maurer-Spurej

LightIntegra Technology Inc.
330-2285 Clark Drive Vancouver, BC, V5N 3G9
t. 604-734-3548 c. 778-991-4122 f. 604.628.7880
www.lightintegra.com
https://www.youtube.com/watch?v=1VuIqLdachk

Current Positions

  • Clinical Associate Professor, Pathology and Laboratory Medicine
  • Adjunct Scientist, R&D Canadian Blood Services
  • Founder & CTO, LightIntegra Technology Inc.

Research Interests

Development and evaluation of new methods of detection for platelet function in the context of transfusion medicine or clinical pathology of bleeding disorders; Dynamic light scattering and its application in platelet quality control, microparticle and bacterial detection, characterization of formulations for liposomal drug delivery and protein biochemistry; Determination of platelet serotonin, specifically in genetic disorders and the effect of selective serotonin reuptake inhibitor (SSRI) antidepressants; Application of biophysical techniques for analysis and understanding of platelet quality and platelet-related diseases. This has resulted in a novel, clinically relevant technology, commercialized as ThromboLUX (www.lightintegra.com) to assess the quality of platelets prior to transfusion.

Selected Publications

  1. Millar, D., Murphy, L., Labrie, A., Maurer-Spurej, E. Routine Screening Method for Microparticles in Platelet Transfusions.  Vis. Exp.(131), e56893, doi:10.3791/56893 (2018).https://www.jove.com/video/56893/routine-screening-method-for-microparticles-in-platelet-transfusions
  2. Kanzler, P, Mahoney, A, Leitner, G, Witt, V, Maurer-Spurej E, Microparticle detection to guide platelet management for the reduction of platelet refractoriness in children – A study proposal. Transfusion Medicine and Hemotherapy. 2017; 56: 39-44.
  3. Maurer-Spurej E, Larsen R, Labrie A, et al.: Microparticle content of platelet concentrates is predicted by donor microparticles and is altered by production methods and stress. Transfus Apher Sci 2016; 55: 35-43.
  4. Maurer-Spurej E, Chipperfield K, Could Microparticles Be the Universal Quality Indicator for Platelet Viability and Function? J Blood Transfus 2016; 2016: 6140239.
  5. Labrie A, Marshall AM, Bedi H, Maurer-Spurej E, Characterization of Platelet Concentrates using Dynamic Light Scattering. Transfusion Medicine and Hemotherapy. 2013; 40:93-100.
  6. Greco CA, Maurer-Spurej E, Scott MD, Kalab M, Nakane N, Ramírez-Arcos SM. PEGylation prevents bacteria-induced platelet activation and biofilm formation in platelet concentrates. Vox Sang. 2011 Apr;100(3):336-9.
  7. Lacroix R, Robert S, Poncelet P, Kasthuri RS, Key NS, Dignat-George F; ISTH SSC Workshop. Standardization of platelet-derived microparticle enumeration by flow cytometry with calibrated beads: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop. J Thromb Haemost. 2010 Nov;8(11):2571-4.
  8. Xu Y, Nakane N, Maurer-Spurej E. Novel test for microparticles in platelet-rich plasma and platelet concentrates using dynamic light scattering. Transfusion. 2011 Feb;51(2):363-70.
  9. Madsen EH, Saw J, Kristensen SR, Schmidt EB, Pittendreigh C, Maurer-Spurej E. Long-term aspirin and clopidogrel response evaluated by light transmission aggregometry, VerifyNow, and thrombelastography in patients undergoing percutaneous coronary intervention. Clin Chem. 2010 May;56(5):839-47.

Education

  • Ph.D.(Chemistry) Karl-Franzens University Graz, Austria, 1991
  • Mster (Chemistry) Karl-Franzens University Graz, Austria, 1988

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