Publications

 

More than an Antibiotic: Unveiling Alternative Therapeutic Potential of Gentamicin

A minor component of gentamicin, an antibiotic used to treat bacterial infections, has the ability to suppress nonsense mutations. This may greatly benefit patients living with rare genetic diseases.

 

Summer Students Visit NetCAD

Summer Studentship students toured the netCAD Blood4Research Facility at UBC and learned about the the cutting-edge services being offered at this facility, putting it at the forefront of transfusion medicine. One blood donation has the potential to help multiple people!

 

Transfusion Medicine “Boot-Less” Camp

Narrowing the transfusion knowledge gap among physicians and residents is critical to improving patient outcomes. "Transfusion Camp" is a new program that is targeting this gap and having far-reaching effects.

 

Kastrup Lab Uses Simulations to Uncover a Potential New Player in Thrombosis

Researchers from the Kastrup Lab at the CBR have provided insight into the mechanism of action for one activator involved in blood clot formation: short‑chain polyphosphate (PolyP).

 

Bromme Lab Makes an Osteoporosis Mouse Model that is More Similar to Humans

All new osteoporosis drugs have failed clinical trials with unexpected severe side effects and no one knew the reason. Now, Bromme Lab at the CBR discovered key differences between mouse and human cathepsin K proteins that can help create more effective mouse models and test for side-effects long before human trials.

 

Kizhakkedathu Lab Develops Heparin Reversal Treatment Without Usual Side-Effects

Published in Blood, Dr. Manu Kalathottukaren showed that the Universal Heparin Reversal Agent (UHRA) developed in Dr. Kizhakkedathu's Lab is non-toxic and has many advantages over the current standard of treatment.

 

CBR Researchers Achieve near Atomic Resolution of Salmonella’s Nano-Syringe

How do pathogenic bacteria manipulate host cells and cause disease? Published in Nature, Dr Strynadka’s lab at CBR solved the structure of the “nano-syringe” Salmonella uses to infect the host and cause disease.

 

Hancock Lab Develops a New Tool for Studying Chlamydia Infection

While the pathological findings of the study will indeed be beneficial to antibiotic development, it is the innovative approach used in creating the in vitro model that must be highlighted.

 

Solving the Mystery: Heparin-induced Thrombocytopenia Without Heparin?

Heparin use is not without consequence as its usage can result in an auto-immune clotting disorder, called heparin-induced thrombocytopenia (HIT). Interestingly, HIT can persist even after heparin has cleared from the body – a mystery that the CBR researchers aimed to solve.

 

Novel Coating Layer to Prevent Medical Device Infections

Dr. Kai Yu developed the best performing medical device coating for preventing catheter-associated urinary tract infections.

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