Publications

Hongjian Xu, Shawna Stanwood, Lilian Nohara (L-R) from the Jefferies Lab

“Red Hot” Discovery by CBR Scientists

Calcium  is a universal second messenger important for brain and immune homeostasis, activation, proliferation, differentiation, and apoptosis. The events surrounding Ca2+ mobilization  are tightly regulated and involve the coordination of diverse ion channels, membrane receptors, and signalling molecules. A calcium channel TRPV1 , has a well-recognized role in nerve cells that help regulate body temperature and alert the brain to […]

Kizhakkedathu team makes breakthrough toward developing universal O donor RBCs

Kizhakkedathu team makes breakthrough toward developing universal O donor RBCs

Through optimizing cell-surface biological reactions, Kizhakkedathu group greatly improved the enzymatic conversion efficiency of A, B and AB red blood cells to universal (O) donor red blood cells.

McNagny et al. provide key insights into longterm effects of antibiotics

McNagny et al. provide key insights into longterm effects of antibiotics

In research led by CBR member, Kelly McNagny, and published in the Journal of Allergy and Clinical Immunology, UBC investigators revealed that different antibiotics affect bacteria that play a positive role in promoting a healthy immune system. They found that receiving antibiotic treatments early in life can increase susceptibility to specific diseases later on. Most […]

A Brooks Discovery: Super Glue for Cells

A Brooks Discovery: Super Glue for Cells

Don Brooks, from the Centre for Blood Research (CBR) at the University of British Columbia, led a group of scientists in Canada to make a super-strong cell membrane adhesive and used it to stick red blood cells together. The polymer, based on the phospholipid head group phosphatidyl choline, could be used to secure cells in […]

Hancock lab tackles malaria by modulating innate immunity

Hancock lab tackles malaria by modulating innate immunity

Severe malaria is a blood borne parasitic disease that afflicts more than 200 million individuals annually. Even in the best clinical settings, case fatality rates remain high since anti-malarial drugs are directed against the parasite but do not reduce life-threatening (brain) inflammation. CBR member Dr. Bob Hancock, Director of the Centre for Microbial Diseases and […]

Lung sections from mice reveals worse evidence of asthma after vancomycin treatment

McNagny and colleagues uncover antibiotic link to asthma

Asthma is a common, increasingly frequent, chronic inflammatory disease of the airways that affects over 100 million people worldwide. It is associated with shortness of breath, coughing and wheezing, and necessitates the use of puffers by millions of children. This treatment is required to prevent considerable short- and long-term morbidity and mortality. Although the cause […]

Hi-Definition HIV Sequencing in the Harrigan Lab

Hi-Definition HIV Sequencing in the Harrigan Lab

Low levels of drug resistant HIV can emerge when exposed to drugs. Researchers at the BC Centre for Excellence in HIV/AIDS have developed a “deep” sequencing approach that gives an in-depth cross-section of the HIV envelope profile in patients. HIV is extracted from patient blood samples and a portion of the envelope gene (which mediates […]

Multiple PI’s “Platelet Investigators” in the Devine Lab

Multiple PI’s “Platelet Investigators” in the Devine Lab

Canadian Blood Services (CBS) investigators Elena Levin, Craig Jenkins, Brankica Culibrk and Katherine Serrano in the lab of Dr. Dana Devine, and Maria Gyongyossy-Issa from the Dept. of Pathology and Laboratory Medicine have been studying the quality of platelets, a key blood transfusion component that is essential to prevent bleeding. These CBR scientists designed a […]

Marissa Jitratkosol and Hélène Côté

Aging in HIV/AIDS: Hélène Côté makes breakthroughs in understanding the risks of HIV therapies

Approximately 3 million HIV-infected women become pregnant every year and approximately 90% of HIV-infected children acquire HIV through mother-to-child transmission. To prevent transmission and/or for their own health, HIV-infected women can receive highly active antiretroviral therapy (HAART) during pregnancy. This greatly decreases the risk of mother-to-child transmission, from 20-25% to <2%. Although the benefits of […]

HPG Polymers Attached to Red Blood Cells

Kizhakkedathu’s polymer lab is on the road to generating universal donor red blood cells

Red blood cell (RBC) transfusions are vital for the treatment of a number of acute and chronic medical problems. Identification of donor RBCs that match the prospective recipient who requires transfusion is occasionally difficult, placing the patient at risk if a match is not available. At present no method is available for the generation of […]